摘要
目的探讨胆囊结石伴血糖异常的代谢、病程特点及疾病防治的临床意义。方法423例经超声检查明确诊断的胆囊结石患者,按空腹血糖(FPG)水平分为血糖正常组(FPG<6.1mmol/L,249例)及血糖异常组(FPG≥6.1mmol/L,l74例)。统计比较两组临床指标[性别、年龄、体质量指数(BMI)、腰臀比值(WHR)、收缩压(SBP)、舒张压(DBP)]、相关代谢指标[FPG、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、尿酸(UA)],并分析4组患者病程情况。结果血糖异常组患者年龄(53.74±5.14)岁大于血糖正常组的(49.75±7.32)岁,BMI(27.25±3.65)kg/m^2、WHR(0.93±0.05)、SBP(130.22±14.77)mmHg(lmmHg=0.133kPa)、DBP(84.53±8.73)mmHg均高于对照组的(24.68±2.86)kg/m^2、(0.87±0.06)、(122.75±15.71)mmHg、(79.42±10.75)mmHg,差异具有统计学意义(P<0.01);血糖正常组患者女性占比36.14%(90/249)高于血糖异常组的21.26%(37/174),差异具有统计学意义(P<0.01)。血糖异常组FPG、TG、TC、UA水平均明显高于血糖正常组,HDL-C水平低于血糖正常组,差异具有统计学意义(P<0.05);两组患者的LDL-C水平比较差异无统计学意义(P>0.05)。血糖异常组患者的胆囊结石病程≥5年者129例(74.1%)、病程<5年者45例(25.9%),血糖异常病程≥5年者29例(16.7%)、病程<5年者145例(83.3%)。血糖正常组患者的胆囊结石病程>10年者45例(18.1%),病程5~10年者69例(27.7%),病程<5年者135例(54.2%)。结论胆囊结石伴血糖异常的患者代谢紊乱的发生更为显著,关注胆囊结石对糖代谢的影响,或有益于糖尿病防治。
Objective To discuss the metabolism,course characteristics of gallstones disease with abnormal blood glucose and the clinical significance of disease prevention and treatment.Methods A total of 423 patients with gallstone disease diagnosed by ultrasound were divided into normal blood glucose group[fasting blood glucose(FPG)<6.1 mmol/L,249 cases]and abnormal blood glucose group(FPG≥6.1 mmol/L,174 cases)according to FPG levels.The clinical indicators[gender,age,body mass index(BMI),waist to hip ratio(WHR),systolic blood pressure(SBP),diastolic blood pressure(DBP)], related metabolic indicators[FPG,total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),triglycerides(TG),uric acid(UA)]of the two groups were compared.The course of disease of the two groups was analyzed.Results The age(53.74±5.14)years old of abnormal blood glucose group was older than(49.75±7.32)years old of normal blood glucose group,BMI(27.25±3.65)kg/m^2,WHR(0.93±0.05),SBP(130.22±14.77)mm Hg(1 mmHg=0.133 kPa)and DBP(84.53±8.73)mm Hg were higher than(24.68±2.86)kg/m^2,(0.87±0.06),(122.75±15.71)mm Hg and(79.42±10.75)mm Hg of the control group,and the difference was statistically significant(P<0.01).The proportion of female in normal blood glucose group was 36.14%(90/249),which was higher than 21.26%(37/174)in abnormal blood glucose group,and the difference was statistically significant(P<0.01).The levels of FPG,TG,TC and UA of abnormal blood glucose group were obviously higher than those of normal blood glucose group,and HDL-C was lower than that of normal blood glucose group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in LDL-C level between the two groups(P>0.05).In the abnormal blood glucose group,129 cases(74.1%)had gallstone course≥5 years,45 cases(25.9%)had disease course<5 years,29 cases(16.7%)had abnormal course of blood glucose≥5 years,145 cases(83.3%)had disease course<5 years.In the normal blood glucose group,4
作者
汪鸿
顾静
祁卉卉
WANG Hong;GU Jing;QI Hui-hui(Department of Gerontology,Huadong Sanatorium,Wuxi 214065,China)
出处
《中国实用医药》
2020年第36期13-16,共4页
China Practical Medicine
关键词
胆囊结石
血糖异常
代谢紊乱
病程
Gallstone disease
Abnormal blood glucose
Metabolic disorder
Course of disease
