摘要
目的探讨布地奈德、阿奇霉素联合特布他林治疗小儿急性支气管炎的效果。方法回顾性分析2018年3月~2019年3月山东省泰安市妇幼保健院收治的96例急性支气管炎患儿的临床资料,根据治疗方式不同将其分为对照组与研究组,每组各48例。对照组患儿采取阿奇霉素、特布他林治疗,研究组患儿在对照组的基础上加用布地奈德治疗。比较两组患儿的症状消失时间、住院时间、血气指标、1秒用力呼气容积(FEV1)、最大呼气流速(MEF50)及最大呼气流速峰值(PEF)。结果研究组患儿的症状消失时间和住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿的氧浓度(FiO2)、动脉血氧分压(PaO2)及二氧化碳分压(PaCO2)比较,差异无统计学意义(P>0.05);治疗后,研究组患儿的FiO2、PaCO2低于对照组,PaO2高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿的FEV1、MEF50、PEF比较,差异无统计学意义(P>0.05);治疗后,研究组患儿的FEV1、MEF50、PEF均高于对照组,差异有统计学意义(P<0.05)。结论对于小儿急性支气管炎可实施布地奈德、阿奇霉素联合特布他林治疗,患儿肺功能明显好转,血气指标有所改善,住院时间缩短,且症状能够在短时间内消失,值得临床推广应用。
Objective To investigate the effect of Budesonide,Azithromycin and Terbutaline on the treatment of children with acute bronchitis.Methods Clinical data of 96 children with acute bronchitis treated in Tai′an Maternal and Child Health Hospital,Shandong Province from March 2018 to March 2019 were retrospectively analyzed and divided into the control group and the study group according to different treatment methods.The control group was treated with Azithromycin and Terbutaline,while the study group was treated with Budesonide on the basis of the control group.The time of symptom disappearance and hospital stay,blood gas indexes,forced expiratory volume in 1 second(FEV1),maximal expiratory flow at 50%of the forced vital capacity(MEF50)and peak expiratory flow(PEF)of the two groups were compared.Results The time of symptom disappearance and hospital stay in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the fraction of inspiration oxygen(FiO2),arterial partial pressure of oxygen(PaO2)and partial pressure of carbon dioxide in artery(PaCO2)between the two groups before treatment(P>0.05).After treatment,the FiO2 and PaCO2 in the study group were lower than those in the control group,PaO2 was higher than that in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in FEV1,MEF50 and PEF between the two groups before treatment(P>0.05).After treatment,the FEV1,MEF50 and PEF in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion For children with acute bronchitis,Budesonide,Azithromycin and Terbutaline in combination can improve lung function and blood gas indexes,shorten the time of symptom disappearance and hospital stay,and symptoms disappearing in a short period of time,which is worthy of clinical promotion and application.
作者
赵娜
ZHAO Na(Department of Pediatrics,Tai′an Maternal and Child Health Hospital,Shandong Province,Tai′an 271000,China)
出处
《中国当代医药》
2021年第1期146-149,共4页
China Modern Medicine
