摘要
目的研究坎地沙坦联合胺碘酮对心力衰竭合并心房颤动患者治疗后心功能及血清炎症因子的变化。方法选择2018年1~12月我院收治的心力衰竭合并心房颤动患者108例,55例以坎地沙坦联合胺碘酮治疗作为观察组,单用胺碘酮治疗53例作为对照组,均随访1年,记录两组患者左室射血分数、6 min步行距离及血清炎症因子水平。结果观察组治疗后左室射血分数(58.67±5.76)%和6 min步行距离(512.65±48.56)m均高于对照组的(53.55±5.38)%和(446.73±43.62)m(P<0.05),观察组治疗后血清炎症因子IL-6、TNF-α[(127.35±13.33)ng/L、(110.34±12.53)ng/L]低于对照组[(135.02±13.89)ng/L、(113.28±12.36)ng/L],其中IL-6比较,差异有统计学意义(P<0.05)。结论坎地沙坦联合胺碘酮治疗可改善心力衰竭合并心房颤动患者心功能并减少其血清炎症因子,临床疗效显著。
Objective To study the effects of candesartan combined with amiodarone on heart function and serum inflammatory factors in patients with heart failure and atrial fibrillation.Methods A total of 108 patients with heart failure and atrial fibrillation admitted to our hospital from January to December 2018 were selected.Fifty-five cases were treated with candesartan combined with amiodarone as the observation group.Fifty-three cases were treated with amiodarone alone as the control group.Both groups were followed up for 1 year.The left ventricular ejection fraction,6-minute walk distance and serum inflammatory factor levels of two groups were recorded.Results After treatment,the left ventricular ejection fraction was(58.67±5.76)%and 6-minute walk distance was(512.65±48.56)m of the observation group were higher than those of the control group([53.55±5.38]%,[446.73±43.62]m)(P<0.05).The serum inflammatory factors IL-6 and TNF-α([127.35±13.33]ng/L,[110.34±12.53]ng/L)in the observation group were lower than those in the control group after treatment([135.02±13.89]ng/L,[113.28±12.36]ng/L),and the difference of IL-6 was statistically significant(P<0.05).Conclusion Candesartan combined with amiodarone therapy can improve heart function and reduce serum inflammatory factors in patients with heart failure and atrial fibrillation,with significant clinical effect.
作者
刘育成
LIU Yucheng(Department of Cardiology,Fujian Provincial Hospital,Fuzhou350001,China)
出处
《中国现代医生》
2020年第31期47-50,共4页
China Modern Doctor
关键词
坎地沙坦
胺碘酮
心力衰竭
心房颤动
心功能
血清炎症因子
Candesartan
Amiodarone
Heart failure
Atrial fibrillation
Heart function
Serum inflammatory factors
