摘要
化疗性脱发(CIA)是绝大多数乳腺癌患者比较惧怕的毒副作用之一,严重影响患者的心理状态及治疗依从性。中医在CIA的防治方面具有较好治疗效果及独特优势,认为发乃血之余、肾藏精生髓、其华在发。CIA的主要病因病机为化疗药邪导致气血亏虚或肝肾阴虚,发失所养;或肝气不舒,气滞血瘀,瘀血阻络,毛窍失养。治疗上以辨证论治为主,分别治以益气养血,滋补肝肾,活血通络。机制研究显示中医药防治CIA可能与抑制促肾上腺皮质激素释放因子受体及前列腺素D2合成酶等有关。
Chemotherapy-induced alopecia(CIA),as one of the frightening side effects for most breast cancer patients,has a negative effect on patients’psychology state and compliance of treatment.Traditional Chinese medicine has unique advantages in the prevention and treatment of CIA with the theory that hair is the surplus of the blood,kidney stores the essence and has its manifestations in hair.The etiology and pathogenesis of CIA in traditional Chinese medicine are that the medicine pathogen of chemotherapeutics can cause the deficiency of both qi and blood as well as the deficiency of liver-kidney yin,thus lead to the undernutrition of hair or the stagnation of liver qi can then cause the combination of qi stagnation and blood stasis syndrome,which makes the stagnated blood lock collaterals,and the hair may also lose nourishment.So the treatment of CIA should be applied by invigorating qi and nourishing blood,tonifying liver and kidney,or promoting blood circulation to remove meridian obstruction respectively based on the traditional Chinese medicine syndrome differentiation and treatment system.Basic medical research showed that the mechanism of Chinese herbs in treating CIA is related to the inhibition of corticotropin-releasing factor receptor and prostaglandin D2 synthetase.
作者
王照东方
周佳琳
刘思达
万冬桂
WANG Zhaodongfang;ZHOU Jialin;LIU Sida;WAN Donggui(Beijing University of Chinese Medicine,Beijing 100029,China;Department of Integrative Medicine Oncology,China-Japan Friendship Hospital,Beijing 100029,China)
出处
《中国医药导报》
CAS
2020年第36期49-52,共4页
China Medical Herald
基金
北京市科技计划项目(D161100005116005)。
关键词
乳腺癌
化疗性脱发
病因病机
中医治疗
Breast cancer
Chemotherapy-induced alopecia
Etiology and pathogenesis
Traditional Chinese medicine therapy
