摘要
目的探讨甲泼尼龙冲击疗法治疗小儿过敏性紫癜的临床效果及其对炎性因子的影响。方法选取2018年1月至2019年4月榆林市第一医院收治的小儿过敏性紫癜病人100例,按随机数字表法分为对照组和观察组,每组50例。对照组给予孟鲁司特钠治疗,观察组病人在对照组基础上给予甲泼尼龙。观察两组病人治疗后临床效果和不良反应,临床症状缓解时间,以及治疗前后血清白细胞介素-6(IL-6),白细胞介素-10(IL-10),肿瘤坏死因子-α(TNF-α),免疫球蛋白A(IgA),免疫球蛋白M(IgM),免疫球蛋白E(IgE)含量变化。结果观察组临床总有效率(96%)高于对照组(82%),不良反应发生率(4%)低于对照组(22%),差异有统计学意义(P<0.05)。观察组病人紫癜消退时间、关节疼痛改善时间、消化道症状改善时间分别为(7.74±1.26)、(3.24±1.13)、(3.72±1.12)d,对照组分别为(8.56±1.32)、(5.42±1.27)、(5.48±1.13)d,观察组均短于对照组,差异有统计学意义(P<0.05)。观察组治疗后IL-6、IL-10、TNF-α、IgA、IgM及IgE水平分别为(23.71±7.14)、(40.73±9.91)、(47.72±7.14)、(2.55±0.45)、(1.11±0.34)、(108.32±17.17)g/L,对照组分别为(27.44±7.22)、(53.31±16.24)、(62.17±7.24)、(3.54±0.43)、(1.28±0.33)、(48.32±17.17)g/L,观察组均低于对照组,差异有统计学意义(P<0.05)。结论甲泼尼龙治疗小儿过敏性紫癜具有较好的临床治疗效果,可有效改善病人的临床症状,降低炎性因子水平,且不良反应率较低,值得临床应用。
Objective To investigate the effect of methylprednisolone pulse therapy on inflammatory factors and clinical effects in children with allergic purpura.Methods A total of 100 patients with pediatric allergic purpura admitted to First Hospital of Yulin from January 2018 to April 2019 were randomly divided into control group and observation group,with 50 cases in each group.Patients in control group were treated with montelukast sodium,while those in observation group were treated with methylprednisolone on the basis of montelukast sodium.The clinical effect,adverse reactions,the clinical symptom remission time,the serum levels of IgA,IgM,IgE,IL-6,IL-10 and TNF-αbefore and after treatment were observed in both groups.Results The total effective rate of the observation group(96%)was significantly higher than that of the control group(82%)(P<0.05),while the adverse reaction incidence of the observation group(4%)was lower than that of the control group(22%),the difference was statistically significant(P<0.05).The purpura regression time,joint pain improvement time,and gastrointestinal symptom improvement time were(7.74±1.26),(3.24±1.13),(3.72±1.12)d,respectively,in the observation group,and(8.56±1.32),(5.42±1.27),(5.48±1.13)d in the control group,those in the observation group were significantly shorter than those in the control group(P<0.05).The levels of serum IL-6,IL-10,TNF-α,IgA,IgM and IgE were(23.71±7.14),(40.73±9.91),(47.72±7.14),(2.55±0.45),(1.11±0.34),(108.32±17.17)g/L in the observation group,and(27.44±7.22),(53.31±16.24),(62.17±7.24),(3.54±0.43),(1.28±0.33),(48.32±17.17)g/L in the control group,those in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Methylprednisolone has a good clinical effect in the treatment of Henoch-Schonlein purpura in children,can effectively improve the clinical symptoms of patients,reduce the level of inflammatory factors,and the adverse reaction rate is low,which is worthy of clinical application.
作者
王英娟
苏乐
贺巧峰
白进
白涛敏
WANG Yingjuan;SU Le;HE Qiaofeng;BAI Jin;BAI Taomin(Department of Paediatrics,First Hospital of Yulin,Yulin,Shaanxi 719000,China;Children’s Hospital of Shaanxi Provincial People’s Hospital,Xi’an,Shaanxi 710068,China)
出处
《安徽医药》
CAS
2021年第1期144-147,共4页
Anhui Medical and Pharmaceutical Journal
基金
陕西省重点研发计划项目(2017SF⁃239)。
