摘要
目的探讨螺内酯在血液透析患者中使用的安全性及其对心血管系统的保护作用。方法选取该院血透中心2019年1—12月维持性血液透析患者102例,在分阶段给予口服螺内酯20 mg隔日至每天1次治疗,观察其高钾血症发生率及血压、心功能指标、颈动脉内膜中层厚度等指标的变化。结果高钾血症发生率较低,且与药物治疗无关,平均血压较治疗前无显著差别,左室舒张末内径、颈动脉内中膜/血管内径、左心室质量指数显著减小(P<0.05),室间隔厚度、左室后壁舒张末期厚度、射血分数较治疗前无显著变化。结论螺内酯20 mg/d在维持性血液透析患者中使用是安全的,并且有改善部分心血管功能指标的作用。
Objective To observe the safety of spironolactone application in the hemodialysis patients and its cardiovascular system protective effect.Methods A total of 102 patients with maintenance hemodialysis in the hemodialysis center of this hospital from January to December 2019 were selected and given spironolactone 20 mg once every other day to once every day.Then the incidence rate of hyperkalemia and the indexes changes of blood pressure,cardiac function and carotid artery intima media thickness were observed.Results The incidence rate of hyperkalemia was low and had no relation to the medication therapy.There was no significant difference of the average blood pressure between before an after operation.LVEDD,carotid artery intima media thickness/vessel diameter and LVMI were significantly decreased(P<0.05),and the interventricular septal thickness,end diastolic thickness of left ventricular posterior wall and ejection fraction had no significant changes compared with those before operation.Conclusion Spironolactone 20 mg/d is safe in the patients with maintenance hemodialysis,moreover has the effect for improving partial cardiovascular function indicators.
作者
聂凌
卢彩宝
王代红
张莹
王沂芹
NIE Ling;LU Caibao;WANG Daihong;ZHANG Ying;WANG Yiqin(Department of Nephrology,Second Affliated Hospital,Army Military Medical University,Chongqing 400037,China)
出处
《重庆医学》
CAS
2020年第24期4133-4135,共3页
Chongqing medicine
基金
陆军军医大学第二附属医院临床科研项目(2016YLC38)。
关键词
螺内酯
血液透析
安全性
心血管系统
spironolactone
hemodialysis
safety
cardiovascular system
