摘要
目的:总结原发性子宫恶性淋巴瘤的临床表现、影像及病理学特点,以期提高对原发性子宫恶性淋巴瘤的认识及诊治水平。方法:通过PubMed、万方、维普、中国知网数据库检索2001年1月至2019年12月报道的原发性子宫恶性淋巴瘤的文献,结合首都医科大学附属北京妇产医院收治的1例原发性子宫大B细胞淋巴瘤的病例资料,对此类患者临床表现、影像及病理学特点、治疗方案及预后进行总结。结果:患者女,64岁,发现盆腔肿物半月伴有绝经后阴道流血,盆腔CT提示:宫体与宫颈局部巨大团块状软组织密度灶,宫底及宫体上段可见内膜。宫腔镜下组织活检病理:(宫内物)符合低分化恶性肿瘤,结合免疫组化结果,诊断原发性子宫大B细胞淋巴瘤。行开腹全子宫及双侧附件、大网膜及腹膜后淋巴结清扫术,术后接受CHOP方案化疗六程,现治疗后随访17月,未发现复发。结论:原发性子宫恶性淋巴瘤极少见,组织学上以大B细胞淋巴瘤为主,临床表现缺乏特异性。最终需要结合免疫组化确诊。该疾病恶性程度高,治疗上以根治性手术联合化疗为主,预后较差。
Objective:To improve the diagnosis and treatment of primary uterine malignant lymphoma.Methods:The literature on primary uterine malignant lymphoma reported from January 2001 to December 2019 was searched by PubMed,Wanfang Med Online,VIP date base and China National Knowledge Infrastructure,and combined with a primary disease admitted to Beijing Obstetrics and GynecologyHospital affiliated to CapitalMedical University.Case data of uterine large B-cell lymphoma were summarized,and the clinical manifestations,imaging and pathological features,treatment options and prognosis of these patients were summarized.Results:A 64 years old female,complaint with vaginal bleeding after menopause,pelvic CT prompt:cervical and lower uterine segment was invaded by massive soft tissue,the fund of the uterus and the endometrial was normal.Hysteroscopic biopsy confirmed as primary uterine large B cell lymphoma.Dissection of the whole uterus and bilateral annexes,omentum and retroperitoneal lymph node was done,complied with CHOP chemotherapy postoperatively for six courses.Conclusion:Primary uterine malignant lymphoma is extremely rare.Its histopathology mainly consists of B-cell lymphoma with high degree of malignancy.Radical surgery is the main treatment and chemotherapy is supplemented.The prognosis of such diseases is poor.
作者
陈芳
段华
王克杨
辛乐
成九梅
CHEN Fang;DUAN Hua;WANG Ke-yang;XIN Le;CHENG Jiu-mei(Department of Gynecological Minimally Invasive Center,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing,100006,China)
出处
《现代生物医学进展》
CAS
2020年第19期3683-3686,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81802742)。
关键词
淋巴瘤
子宫
恶性
手术治疗
Lymphoma
Uterus
Malignant
Surgical treatment
