摘要
目的探讨氨茶碱联合地塞米松对羊水栓塞产妇不良反应及凝血功能的影响。方法选取2015年1月至2019年1月海南现代妇婴医院收治的62例羊水栓塞产妇作为研究对象。依据随机数字表法分为观察组(n=31)与对照组(n=31)。对照组产妇给予地塞米松,观察组产妇在对照组基础上联合应用氨茶碱。比较两组产妇疗效、治疗前后凝血功能变化及不良反应发生情况。结果观察组产妇总有效率(96.77%)高于对照组产妇(77.42%),差异具有统计学意义(P<0.05)。治疗后,两组产妇PT和APTT较治疗前缩短,而Fib水平较治疗前升高,差异具有统计学意义(P<0.05);治疗后,观察组产妇PT和APTT短于对照组产妇,Fib水平高于对照组产妇,差异具有统计学意义(P<0.05)。观察组产妇不良反应发生率(6.45%)低于对照组产妇(29.03%),差异具有统计学意义(P<0.05)。结论氨茶碱联合地塞米松治疗羊水栓塞产妇的疗效良好,不良反应少,可改善产妇凝血功能,值得临床借鉴。
Objective To investigate the effects of aminophylline combined with dexamethasone on adverse reactions and coagulation function in women with amniotic fluid embolism.Methods A total of 62 women with amniotic fluid embolism admitted to Hainan Modern Women&Infants Hospital from January 2015 to January 2019 were divided into observation group(n=31)and control group(n=31)according to the random number table method.Control group were given dexamethasone,observation group were given dexamethasone combined with aminophylline.The curative effect,change of coagulation function and occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group(96.77%)was higher than that in the control group(77.42%),and the difference was statistically significant(P<0.05).After treatment,PT and APTT of the two groups were shortened,while Fib level was increased,and the difference was statistically significant(P<0.05).After treatment,PT and APTT in the observation group were shorter than those in the control group,and Fib level was higher than that in the control group,with statistically significant differences(P<0.05).The incidence of maternal adverse reactions in the observation group(6.45%)was lower than that in the control group(29.03%),and the difference was statistically significant(P<0.05).Conclusions Aminophylline combined with dexamethasone in the treatment of women with amniotic fluid embolism has good curative effect and few adverse reactions.It can improve the coagulation function of women with amniotic fluid embolism and is worthy of clinical reference.
作者
李日芳
刘彬
宋英
鲍红玉
LI Rifang;LIU Bin;SONG Ying;BAO Hongyu(Department of Obstetrics and Gynecology,Hainan Modern Women&Infants Hospital,Haikou 571106,Hainan,China)
出处
《中国性科学》
2020年第12期88-91,共4页
Chinese Journal of Human Sexuality
关键词
氨茶碱
地塞米松
羊水栓塞
不良反应
凝血功能
Aminophylline
Dexamethasone
Amniotic fluid embolism
Adverse reactions
Coagulation function
