摘要
血糖控制不良是糖尿病慢性并发症形成的主要危险因素之一。其中,血糖变异性与持续性高血糖状态相比,对糖尿病患者产生的危害更大。血糖变异性可能通过氧化应激、炎性反应、内皮功能障碍、细胞凋亡等病理生理学机制,参与糖尿病大血管、微血管及神经病变等多种并发症的发生、发展,影响患者心理健康、增加致残率及致死率,加重全社会的医疗卫生负担。从药物选择、营养因素、血糖监测、胰岛素注射技术等方面进行优化,可能起到改善血糖变异性、提高糖尿病治疗水平的作用。
Poor glycemic control is one of the main risk factors for diabetic chronic complications.Among them,blood glucose variability is more harmful to diabetic patients than persistent hyperglycemia.Blood glucose variability may participate in the occurrence and development of multiple complications such as diabetic macrovascular diseases,microvascular diseases and neuropathy through oxidative stress,inflammatory response,endothelial dysfunction,apoptosis and other pathophysiological mechanisms.The disability rate and mortality rate increase the medical and health burden of the whole society.Optimization from the aspects of drug selection,nutritional factors,blood glucose monitoring,and insulin injection technology may play roles in improving blood glucose variability and improving the level of diabetes treatment.
作者
张雪
匡洪宇
Zhang Xue;Kuang Hongyu(Department of Endocrinology,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《国际内分泌代谢杂志》
2020年第6期408-411,共4页
International Journal of Endocrinology and Metabolism
关键词
血糖变异性
糖尿病慢性并发症
治疗
危险因素
Blood glucose variability
Diabetic chronic complications
Treatment
Risk factors
