摘要
非酒精性脂肪性肝病(NAFLD)是以肝脏脂质堆积为特征的一系列临床病理综合征。随着肥胖及代谢综合征患病率的升高,NAFLD已成为慢性肝脏疾病的首位病因。姜黄素是从姜黄根中提取的天然多酚类物质,具有抗炎、抗氧化、抗肿瘤等作用,并已在多种疾病中得到应用。近年来研究发现,姜黄素在肥胖及相关代谢紊乱中具有重要的调控作用,可抑制脂质生成,促进分解氧化,增强胰岛素敏感性,改善肝脏糖、脂代谢。同时,姜黄素可改善肝脏线粒体功能,增加线粒体生物合成,降低细胞内氧化应激水平,抑制细胞凋亡等。此外,姜黄素通过调控循环及组织中细胞因子的含量,改善肝脏脂质水平及损伤。因此,姜黄素可能成为NAFLD的潜在治疗药物。
Nonalcoholic fatty liver disease is a series of clinical pathological syndrome characterized by accumulation of lipids in the liver.With the increasing prevalence of obesity and metabolic syndrome,it has become the leading cause of chronic liver diseases.Curcumin is a natural polyphenolic substance extracted from turmeric.It has been used in a variety of diseases for the anti-inflammatory,anti-oxidant and anti-tumor effects.In recent years,studies have found that curcumin has an important role in obesity and related metabolic diseases.Curcumin can inhibit fatty acid synthesis,promote lipolysis and oxidation,enhance insulin sensitivity,improve liver glucose and lipid metabolism.Curcumin can also improve liver mitochondrial function by reducing mitochondrial oxidative stress,increasing biosynthesis and inhibiting apoptosis.In addition,curcumin improves liver metabolism by regulating the expression of cytokines in circulation and tissues.Therefore,curcumin may be a potential therapeutic drug for nonalcoholic fatty liver disease.
作者
杜苏苏
李晓南
Du Susu;Li Xiaonan(Department of Child Health Care,Children′s Hospital of Nanjing Medical University,Nanjing 210008,China)
出处
《国际内分泌代谢杂志》
2020年第6期399-402,407,共5页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金(81773421)
江苏省医学创新团队(CXTDA2017035)。
关键词
姜黄素
非酒精性脂肪性肝病
糖脂代谢
线粒体
炎症
细胞因子
Curcumin
Nonalcoholic fatty liver disease
Glucose and lipid metabolism
Mitochondria
Inflammation
Cytokines
