摘要
目的:探讨药物基因检测在个体化给药、安全用药及指导合理用药中的作用和意义。方法:收集本院2019年5~8月的药物基因检测报告,对检测结果进行统计分析。结果:通过药物基因检测后,在阿司匹林使用患者中,21例(12.14%)更换了治疗方案,3例(1.96%)需要密切监测药物不良反应;在氯吡格雷使用患者中,95例(58.28%)需要进行剂量调整及药物更换;在华法林使用患者中,2例(18.18%)进行了剂量调整;在他汀类药物使用患者中,5例(4.88%)进行了剂量限制和药物不良反应监测;在卡马西平使用患者中,3例(37.5%)需要警示严重不良反应发生并更换治疗药物。结论:通过药物基因检测开展必要的药学服务,予以指导临床用药,并促进个体化用药。
Objective:The purposes are to explore the role of pharmacogenetic testing in individual drug administration,safe use of drug and guidance of clinical rational drug use.Methods:We collected pharmacogenetic testing reports participated by clinical pharmacists from May 2019 to August 2019 and analyzed the testing results.There were 429 cases of pharmacogenetic testing,mainly involved 173 cases of aspirin(40.33%),163 cases of clopidogrel(38.00%),11 cases of warfarin(2.56%),41 cases of statins(9.56%)and 8 cases of carbamazepine.All the cases covered 6 clinical departments of the hospital.Results:Based on the pharmacogenetic testing results,21 cases(12.14%)of aspirin needed a change of treatment regimen,3 cases of aspirin needed close monitoring on adverse drug reactions;95 cases(58.28%)of clopidogrel needed dose adjustment and drug replacement;2 cases(18.18%)of warfarin needed dose adjustment;5 cases(4.88%)of statin needed dose limitation and adverse drug reaction monitoring;3 cases of carbamazepine needed pharmacovigilance of serious adverse reactions and change of therapeutic drugs.Conclusion:The work of pharmacogenetic testing in our hospital had a significant effect.It is necessary to carry out pharmaceutical care with pharmacogenetic testing.Pharmacogenetic testing can guide the use of clinical drug and promote individual drug use.
作者
钱豪英
李榕
后晓群
蔡沁雯
周剑斌
舒薇
QIAN Haoying;LI Rong;HOU Xiaoqun;CAI Qinwen;ZHOU Jianbin;SHU Wei(Shanghai Jing'an District Zhabei Center Hospital,Shanghai 200070,China)
出处
《药学与临床研究》
2020年第6期438-442,共5页
Pharmaceutical and Clinical Research
关键词
药物基因检测
临床药师
个体化用药
Pharmacogenetic testing
Clinical pharmacist
Individualized medication
