摘要
预防性疫苗的接种是针对传染病最经济和最有效的防治措施,被评为二十世纪最伟大的公共卫生成就。疫苗也被认为可能是肿瘤、代谢性疾病、退行性疾病等慢病最具潜力的防治手段。疫苗涉及国家安全,是国家战略医药产业之一,因此提升疫苗研发能力必须作为国家战略进行布局。2019年国家自然科学基金委员会医学科学部、生命科学部、信息科学部、化学科学部与政策局联合主办了“重大疾病疫苗研究的关键科学问题”双清论坛,专家围绕疫苗免疫原、佐剂、递送系统、疫苗效应的免疫保护性与免疫记忆机制、疫苗研制的新策略与新系统与技术进展、疫苗流行病学、疫苗评价技术体系建立等主题研讨,分析了疫苗研究面临的挑战,提出了我国重大疾病疫苗研究的战略方向。本文为这次双清论坛的学术综述。
Prophylactic vaccination is one of the most cost-effective preventions and control measures for infectious diseases and is regarded as one of the most outstanding public health achievements of the 20th century.Vaccines are also supposed to be one of the most potential prevention and treatment agents for chronic diseases such as tumors,metabolic diseases and senile cognitive diseases.As a part of the national strategic pharmaceutical industry,vaccine supply concerns national security.Therefore,the promoting of vaccine research and development capacity must be implemented as national strategy.In 2019,the Department of Health Sciences,the Department of Life Sciences,the Department of Information Sciences,the Department of Chemical Sciences,and the Policy Bureau of National Natural Science Foundation of China jointly hosted the Shuangqing Forum on‘Critical Scientific Inquiries on Vaccine Development against Major Diseases’.The focuses of expert discussion included vaccine immunogen,adjuvant,delivery system,immune protective mechanism of vaccine effect,mechanism of vaccine immune memory,new strategy,and new system and technology progress of vaccine development,vaccine epidemiology,and the establishment of vaccine evaluation technology system.Latent challenges of vaccine research were analyzed in the forum,and the strategic direction of vaccine research for major diseases in China was put forward.In this specific issue,the academic summary of the forum is presented for the reference of the community.
作者
洪微
徐岩英
孙瑞娟
Hong Wei;Xu Yanying;Sun Ruijuan(Department of Health Sciences,National Natural Science Foundation of China,Beijing100085)
出处
《中国科学基金》
CSCD
北大核心
2020年第5期537-547,共11页
Bulletin of National Natural Science Foundation of China
关键词
疫苗免疫原
佐剂
疫苗效应
免疫记忆
免疫策略
流行病学
vaccine immunogen
adjuvant
vaccine efficacy
immune memory
immune strategy
epidemiology
