摘要
目的:探究参麦注射液对不同中医证型冠心病患者心电图改变的影响情况。方法:将采用参麦注射液治疗的271例冠心病患者,按中医辨证理论,分为4个中医组:72例心肾阴虚组,69例痰浊痹阻组,56例心血痹阻组,74例气阴两虚组;随机选取同时期单纯采用西医治疗的67例冠心病患者作为对照组。对比5组治疗前后心电图校正最小QT间期(QTcmin)、校正最大QT间期(QTcmax)和校正QT间期离散度(QTcd);校正最小JT间期(JTcmin)、校正最大JT间期(JTcmax)和校正JT间期离散度(JTcd);房室传导阻滞例数;缺血型T波例数;ST段异常例数;测量V1导联P波的负向波振幅及宽度的乘积(PTF-V1)≤-0.04 mm·s的例数。结果:5组治疗后,QTcmin、QTcmax及QTcd指标比较,差异有统计学意义(P<0.05);气阴两虚组相比对照组、心肾阴虚组、心血痹阻组和痰浊痹阻组降低;4个中医组QTcd低于对照组,差异有统计学意义(P<0.05)。5组治疗后,JTcmin、JTcmax及JTcd指标相互比较,差异有统计学意义(P<0.05);气阴两虚组相比对照组、心肾阴虚组、心血痹阻组和痰浊痹阻组降低;4个中医组JTcd明显低于对照组,差异有统计学意义(P<0.05)。5组治疗后,房室传导阻滞、PTF-V1≤-0.04 mm·s发生率比较,差异有统计学意义(P<0.05);气阴两虚组低于对照组、心肾阴虚组,差异有统计学意义(P<0.05)。结论:参麦注射液可以有效降低不同中医证型冠心病心电图QTcmin、QTcmax、QTcd、JTcmin、JTcmax和JTcd指标,降低房室传导阻滞和PTF-V1≤-0.04 mm·s的发生例数,对气阴两虚型改善效果尤为显著。
Objective:To discuss the effect of Shenmai injection on electrocardiogram changes in patients with coronary heart disease of different Chinese medicine syndrome types. Methods: According to the theory of Chinese medicine syndrome differentiation, a total of 271 cases of patients with coronary heart disease who were treated with Shenmai injection were divided into four groups of Chinese medicine:the group of heart-kidney yin deficiency(72 cases),the group of phlegm-turbidity obstruction(69 cases),the group of heart blood obstruction(56 cases),and the group of qi-yin deficiency(74 cases). A total of 67 cases of patients with coronary heart disease who were given simple western medicine at the same period were randomly selected as the control group. Before and after treatment,minimum corrected QT interval(QTcmin),maximum corrected QT interval(QTcmax),and corrected QT interval dispersion(QTcd) of electrocardiogram were compared in the five groups;minimum corrected JT interval(JTcmin), maximum corrected JT interval(JTcmax), and corrected JT interval dispersion(JTcd) were compared in the five groups;the number of cases of atrioventricular block,ischemic T wave,and abnormal ST segment was compared in the five groups. PTF-V1 was defined as the product of the duration and amplitude of the P-wave during the negative phase shown in lead V1. The number of cases of PTF-V1≤-0.04 mm·s was measured.Results: After treatment, there was significant difference being found in the comparison of indexes including QTcmin,QTcmax, and QTcd among the five groups(P<0.05). After treatment, the QTcmin, QTcmax, and QTcd in the qi-yin deficiency group were decreased when compared with those in the control group as well as the groups of heart-kidney yin deficiency,heart blood obstruction,and phlegm-turbidity obstruction;the QTcd in the four groups of Chinese medicine were lower than that in the control group,the difference being significant(P<0.05). After treatment,there was significant difference being found in the inter-comparison of indexe
作者
赵凤娟
黄伟刚
俞梅
何伟明
ZHAO Fengjuan;HUANG Weigang;YU Mei;HE Weiming
出处
《新中医》
CAS
2020年第22期63-66,共4页
New Chinese Medicine
基金
浙江省中医药科技计划项目(2014ZB124)。
关键词
冠心病
中医证型
参麦注射液
心电图
Coronary heart disease
Chinese medicine syndrome types
Shenmai injection
Electrocardiogram
