摘要
目的:分析正畸微型种植体对安氏Ⅱ类错颌畸形患者基质金属蛋白酶2(MMP-2)、基质金属蛋白酶9(MMP-9)及B淋巴细胞瘤-2蛋白(Bcl-2)与Bcl-2相关X蛋白(Bax)比值Bcl-2/Bax水平的影响。方法:选取2018年1月至2019年12月110例医院收治安氏Ⅱ类错颌畸形患者,随机数字表法简单随机分为观察组与对照组。对照组采取传统正畸治疗方案,观察组则采取微型种植体治疗。观察两组患者治疗前后MMP-2、MMP-9及Bcl-2/Bax水平的变化,并统计两组患者治疗期间并发症发生率差异。结果:重复测量方差分析显示,MMP-2、MMP-9不同组间、不同时点间的差异及分组与时点的交互作用均有统计学意义(均P<0.05),且对照组治疗前后MMP-2、MMP-9值升高较观察组显著(P<0.05);重复测量方差分析显示,Bcl-2/Bax值不同组间、不同时点间的差异及分组与时点的交互作用均有统计学意义(均P<0.05),且对照组治疗前后Bcl-2/Bax值降低较观察组显著(P<0.05);观察组治疗期间并发症发生率为5.45%和18.18%,两组间的比较差异有统计学意义(P<0.05)。结论:微型种植体在安氏Ⅱ类错颌畸形患者正畸治疗中所引起的炎症因子水平要低于传统正畸治疗方案,有助于减小正畸治疗对牙周组织造成的损伤,且并发症更少,值得推广使用。
Objective:To analyze the effect of orthodontic micro-implant on MMP-2、MMP-9 and Bcl-2/Bax levels in patients with class II malocclusion.Methods:110 patients admitted from January 2018 to December 2019 with class II malocclusion were randomly divided into observation group and control group.The control group had traditional orthodontic treatment,while the observation group had microimplant.The changes of MMP-2、MMP-9 and Bcl-2/Bax levels before and after treatment were observed,and the incidence of complications was different.Result:Repeated measurement analysis of variance showed that the differences of MMP-2 and MMP-9 between different groups and time points and the interaction between groups and time points were statistically significant(all P<0.05),and the increase of MMP-2 and MMP-9 in the control group was significantly higher than that in the observation group(P<0.05);the repeated measurement analysis of variance showed that the difference of Bcl-2/Bax value between different groups and time points,and the interaction between groups and time points were statistically significant(all P<0.05),and the Bcl-2/Bax value in the control group was significantly lower than that in the observation group(P<0.05).The incidence rates of complications during treatment in the observation group were 5.45% and 18.18%,and the difference between the two groups was statistically significant(P<0.05).Conclusion:The level of inflammatory factors caused by micro implants in orthodontic treatment of patients with class II malocclusion is lower than that of traditional orthodontic treatment,which is helpful to reduce the damage caused by orthodontic treatment to periodontal tissue,and the complications are less.So it is worth popularizing.
作者
袁瑛
王伦昌
YUAN Ying;WANG Lunchang(Guangyuan Central Hospital,Sichuan Guangyuan 628000,China)
出处
《河北医学》
CAS
2020年第12期2053-2056,共4页
Hebei Medicine
基金
四川省卫生和计划生育科研课题项目,(编号:17PJ434)。
