摘要
目的探讨老年住院患者血清25羟基维生素D [25(OH)D]与肌少症的相关性。方法选择2016年9月-2019年3月西部战区总医院收治的142例老年患者,分为肌少症和非肌少症2组,收集2组年龄、性别、BMI、甲状旁腺激素、白蛋白、血清钙、25(OH)D、NRS2002数据进行相关性分析;按年龄将患者分为3组:65~74岁年龄组(n=43)、75~84岁年龄组(n=46)和≥85岁年龄组(n=53),比较分析3组患者的BMI、甲状旁腺激素、白蛋白、血清钙、25(OH)D、NRS2002、握力、步速、相对骨骼肌质量(RASM)等指标;再按照25(OH)D水平,将各年龄组患者分为2个亚组:A组(≥50nmol/L)和B组(<50nmol/L),分别对不同年龄组各亚组相关数据进行比较分析。结果年龄、BMI、25(OH)D、NRS2002是肌少症独立危险因素。随着年龄增长,患者25(OH)D水平降低(P<0.05),肌少症发生率升高,同一年龄段B组发生率更高。各年龄亚组比较,A组握力、步速、RASM、NRS2002均优于B组(P<0.05),肌少症发生率低于B组。75~84岁年龄段两亚组比较,步速、握力差异有统计学意义(P<0.05)。≥85岁年龄段两亚组比较,握力、RASM差异有统计学意义(P<0.05)。结论 25(OH)D是预测肌少症的独立危险因子,且25(OH)D降低与增龄有关。25(OH)D降低可能通过影响患者握力、步速、肌力等因素导致肌少症的发生,且营养不良伴随其中。
Objective To explore the correlation between serum 25 hydroxyvitamin D [25(OH) D] and sarcopenia in the hospitalized elderly patients. Methods A total of 142 elderly patients admitted to the General Hospital of Western Theater Command from September 2016 to March 2019 were enrolled and divided into myopenia group and non-myopenia group. The data of age, gender, BMI, parathyroid hormone, albumin, serum calcium, 25(OH) D and NRS2002 scores of both groups were collected for correlation analysis. The patients were divided into three groups according to age: 65-74 years old group(n=43), 75-84 years old group(n =46) and ≥ 85 years old group(n=53). BMI, parathyroid hormone, albumin, serum calcium,25(OH) D, NRS2002 score, grip strength, walking speed and relative appendicular skeletal muscle mass(RASM) were analyzed and compared among the three groups. According to the 25(OH) D level, the patients of each age group were further divided into two subgroups: group A(≥50 nmol/L) and group B(<50 nmol/L). The related data of different age subgroups were analyzed and compared. Result Age, BMI, 25(OH) D and NRS2002 score were independent risk factors for sarcopenia.With the increase of age, the level of 25(OH) D decreased(P<0.05), the incidence of sarcopenia increased, and the incidence of group B was higher than that of group A in the same age groups. In the comparison of various age subgroups, the grip strength,pace, RASM, and NRS2002 score of group A were better than those of group B(P<0.05), and the incidence of sarcopenia was lower than that of group B. There were significant differences in walking speed and grip strength between the two subgroups of75-84 years old group(P< 0.05);there were significant differences in grip strength and RASM between the two subgroups of≥85 years old group(P<0.05). Conclusion 25(OH) D is an independent risk factor predicting sarcopenia, and the decrease of 25(OH) D is related to aging. The decrease of 25(OH) D may lead to the occurrence of sarcopenia by influencing the grip strength, wal
作者
许婷媛
徐贤华
张汝
Xu Tingyuan;Xu Xianhua;Zhang Ru(Cadre Ward,General Hospital of Western Theater Command of PLA,Chengdu,Sichuan,610083,P.R.China)
出处
《老年医学与保健》
CAS
2020年第6期976-979,共4页
Geriatrics & Health Care
基金
四川省卫计委课题(16PJ016)。
关键词
老年
肌少症
住院
维生素D
elderly
sarcopenia
in hospital
vitamin D
