摘要
随着生物技术的发展与应用,许多未知的细菌陆续被发现。同时,随着环境的变化,一些已知的细菌不断产生新的致病或耐药表型。面对细菌日益复杂的威胁,开展细菌进化及其与经典致病菌的亲缘关系的研究,探究细菌新种属或新表型的产生机制,将为防控以及治疗细菌感染提供重要的参考依据。由于基因组携带着物种所有的遗传信息,基于细菌基因组数据开展进化研究可更真实地还原物种的进化过程。目前,测序等分子生物学技术的发展,为深入了解细菌的进化过程及遗传和功能特性等提供了更有力的技术支持。
As the development and application of biological technology,many unknown bacteria have been identified gradually.Meanwhile,with environment changing,some known pathogenic bacteria have evolved new phenotypes involved in pathopoiesia or resistance.In the face of growing threats,carrying out research in bacteria evolution and its relationship with classical pathogens and exploring the emerging mechanisms of new pathogen or new phenotypes would provide a reference for the prevention and controlling of pathogens.Because the genome carries all the genetic information of a species,the research based on the bacterial genome analysis would present a more realistic evolutionary process.Especially,the development of the molecular biotechnology,such as sequencing,will provide powerful tools for understanding the evolutionary process and mechanisms and their genetic traits and functional characteristics of bacteria.
作者
迟文静
刘宜昕
王粟
刘涛
赵虎
张艳梅
CHI Wenjing;LIU Yixin;WANG Su;LIU Tao;ZHAO Hu;ZHANG Yanmei(Department of Clinical Laboratory,Huadong Hospital,Fudan University,Shanghai 20004,China)
出处
《检验医学》
CAS
2020年第12期1310-1314,共5页
Laboratory Medicine
基金
上海市科委引导类科技支撑项目(18411960600)
上海申康医院发展中心新型前沿技术联合攻关项目(SHDC12015107)
上海市科委科技创新行动计划(18411950800)。
关键词
细菌
进化树
基因组
亲缘关系
Bacterium
Evolutionary tree
Genome
Phylogeny
