摘要
目的探讨平均血小板体积(MPV)作为卵巢癌新型预后生物标志物的可行性。方法回顾性分析2011年1月—2014年1月在徐州医科大学附属医院接受手术治疗的170例卵巢癌患者的临床资料,根据MPV水平将研究对象分为MPV≥9.7 fL组(117例)和MPV<9.7 fL组(53例)。分析MPV水平与临床病理数据之间的关系;评估MPV水平对卵巢癌患者5年总体生存时间(OS)的影响。结果MPV与血红蛋白(Hb)、白细胞(WBC)计数、血小板(PLT)计数、2014年国际妇产科联盟(FIGO)分期之间具有相关性(P<0.05)。Kaplan-Meier生存分析结果显示,MPV<9.7 fL组患者的5年OS明显短于MPV≥9.7 fL组(P<0.001)。多因素Cox回归分析发现,MPV是卵巢癌患者预后不良的独立影响因素。结论MPV降低是卵巢癌患者预后不良的影响因素。
Objective To investigate the feasibility of mean platelet volume(MPV)as a prognostic biomarker for ovarian cancer.Methods The clinical data of 170 patients with ovarian cancer who underwent surgery at the Affiliated Hospital of Xuzhou Medical University from January 2011 to January 2014 were analyzed retrospectively.The patients were classified into MPV≥9.7 fL group(117 cases)and MPV<9.7 fL group(53 cases).The relationship between MPV levels and clinical pathological data was analyzed.The influence of MPV levels on 5-year overall survival(OS)in patients with ovarian cancer was evaluated.Results There was a correlation between the 2 groups for hemoglobin(Hb),white blood cell(WBC)count,platelet(PLT)count and the stages of the International Federation of Obstetrics and Gynecology of 2014(FIGO)(P<0.05).Kaplan-Meier survival analysis showed that the OS in MPV<9.7 fL group was shorter than that in MPV≥9.7 fL group(P<0.001).Multivariate Cox regression analysis showed that MPV was an independent influencing factor for poor prognosis in patients with ovarian cancer.Conclusions The decreasing of MPV is an influential factor for poor prognosis in patients with ovarian cancer.
作者
杨焕
周臣
陆晓媛
YANG Huan;ZHOU Chen;LU Xiaoyuan(Affiliated Hospital of Xuzhou Medical University,Xuzhou 221002,Jiangsu,China)
出处
《检验医学》
CAS
2020年第12期1255-1258,共4页
Laboratory Medicine
