摘要
肠道菌群在机体营养物质吸收、代谢和免疫防御等方面起着关键作用,其代谢产物胆汁酸(BA)不仅能促进脂溶性物质的吸收,还可作为信号物质激活法尼酯X受体(FXR)和G蛋白胆汁酸偶联受体5(TGR5),影响FXR/TGR5介导的信号通路,调节宿主代谢。本文主要综述了肠道菌群对BA代谢及相关通路的影响,旨在为调控动物脂肪沉积、防治机体糖代谢紊乱和炎症等提供依据。
Intestinal microflora plays a key role in nutrient absorption,metabolism and immune defense.The metabolite bile acid(BA)produced by intestinal microflora can not only promote the absorption of fat-soluble substances,but also act as a signaling molecule to activate farnesoid X receptor(FXR)and Takeda G-protein-coupled receptor 5(TGR5),affecting FXR/TGR5-mediated signaling pathways and regulating host metabolism.Therefore,this paper mainly reviews the effect of intestinal microflora on BA metabolism and related pathways,aiming to provide basis for regulating animal fat deposition,preventing and treating diseases such as glucose metabolism disorder and inflammation.
作者
刘鑫
黎力之
关玮琨
张海波
刘小高
LIU Xin;LI Lizhi;GUANG Weikun;ZHANG Haibo;LIU Xiaogao(College of Life Science and Environmental Resource,Engineering Technology Research Center of Jiangxi Universities and Colleges for Selenium Agriculture,Yichun Key Laboratory of Functional Agriculture and Ecological Environment,Yichun University,Jiangxi Yichun 336000,China)
出处
《中国畜牧杂志》
CAS
北大核心
2020年第12期13-19,共7页
Chinese Journal of Animal Science
基金
国家地区科学基金项目(32060773)
江西省教育厅项目(GJJ190848)
宜春学院博士科研启动基金(3350100050)。
关键词
肠道菌群
胆汁酸
法尼酯X受体
G蛋白胆汁酸偶联受体5
信号通路
Intestinal microflora
Bile acid
Farnesoid X receptor
Takeda G-protein-coupled receptor 5
Signaling pathway
