摘要
目的探索相位对比磁共振成像(phase contrast magnetic resonance imaging,PC-MRI)技术在无创评估颅内顺应性方面的价值。方法2019年10-12月解放军总医院第一医学中心招募30例健康年轻志愿者[(28.93±4.24)岁;男女比例17∶13],采用自身前后对照研究比较Valsalva动作前、后两种状态的颈内动脉(internal carotid artery,ICA)和颈内静脉(internal jugular vein,IJV)血管面积、相对波峰时间(rTimepeak)和收缩期ICA至IJV波峰传导时间(TTICA-IJV)。结果Valsalva动作状态相较于平静呼吸状态,IJV面积显著增大[40.29(25.70,58.09)mm2 vs 52.64(33.37,69.71)mm2;P<0.001],ICA面积减小[19.99(15.82,22.74)mm2 vs 18.79(15.08,22.25)mm2;P=0.016],ICA的rTimepeak延后[213.66(190.50,237.00)ms vs 230.50(206.00,271.00)ms;P<0.001],IJV的rTimepeak提前[320.00(271.00,382.25)ms vs 270.25(3.10,5.28)ms;P=0.003],TTICA-IJV显著缩短[103.50(67.25,160.25)ms vs 28.00(5.50,49.00)ms;P<0.001],TTICA-IJV缩短的程度与平静呼吸时IJV的rTimepeak呈显著正相关(r=0.75,P<0.001)。结论采用基于PC-MRI测量的TTICA-IJV和平静呼吸时IJV的rTimepeak是具有潜在应用价值的无创评估颅内顺应性指标。
Objective To explore the feasibility and value of phase contrast magnetic resonance imaging(PC-MRI)technique in noninvasive evaluation of intracranial compliance.Methods From October to December in 2019,thirty young healthy volunteers(28±5 years old;17 males and 13 females)were recruited and underwent PC-MRI in the First Medical Center of Chinese PLA General Hospital with same scanning parameters under different breathing conditions:normal breathing(NB)and Valsalva maneuver(VM).The vascular areas,the relative systolic peak waveform time(rTimepeak)and the systolic transient time of the peak waveform from internal carotid artery to internal jugular vein(TTICA-IJV)were compared between different conditions.Results Compared to NB,during VM,the area of IJV significantly increased(40.29[25.70,58.09]mm2 vs 52.64[33.37,69.71]mm2;P<0.001),while the area of ICA decreased(19.99[15.82,22.74]mm2 vs 18.79[15.08,22.25]mm2;P=0.016).The rTimepeak of ICA delayed(213.66[190.50,237.00]ms vs 230.50[206.00,271.00]ms;P<0.001),and the rTimepeak of IJV advanced(320.00[271.00,382.25]ms vs 270.25[3.10,5.28]ms;P=0.003),TTICA-IJV shortened(103.50[67.25,160.25]ms vs 28.00[5.50,49.00]ms;P<0.001),and the difference of TTICA-IJV between NB and VM was positively correlated with the rTimepeak of IJV in NB(r=0.75,P<0.001).Conclusion TTICA-IJV and rTimepeak of IJV measured by PC-MRI have potential application value in noninvasive evaluation to intracranial compliance.
作者
鱼笑
冯杰
刘洁
边祥兵
刘文佳
马林
YU Xiao;FENG Jie;LIU Jie;BIAN Xiangbing;LIU Wenjia;MA Lin(Chinese PLA Medical School,Beijing 100853,China;Department of Radiology,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Department of Radiology,General Hospital of Tibet Military Region,Lhasa 858007,Tibet,China)
出处
《解放军医学院学报》
CAS
2020年第10期1011-1016,1041,共7页
Academic Journal of Chinese PLA Medical School
基金
国家自然科学基金项目(81741115)
军事医学创新工程专项(16CXZ014)
军队保健专项课题(16BJZ11)。
关键词
颅内压
颅内顺应性
磁共振成像
相位对比
脑静脉
intracranial pressure
intracranial compliance
magnetic resonance imaging
phase contrast
cerebral vein
