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深圳市2016-2019年异烟肼耐药结核病患者治疗转归分析 被引量:3

Treatment outcome of isoniazid-resistant tuberculosis in Shenzhen,2016-2019
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摘要 目的分析深圳市异烟肼耐药结核病(isoniazid-resistant tuberculosis,Hr-TB)患者的治疗转归情况,为今后进一步优化Hr-TB治疗方案及防控措施提供科学依据。方法收集2016年1月至2019年1月纳入深圳市耐药结核病管治项目登记治疗Hr-TB患者的登记本,对2020年2月前全部完成疗程并已结案的Hr-TB患者的治疗转归情况及未成功治疗原因进行分析。结果纳入分析的Hr-TB患者共144例,102例(70.83%)成功治疗,42例(29.17%)未成功治疗;不同性别、户籍及治疗方案中含左氧氟沙星(Levofloxacin,Lfx)方案与未含Lfx方案患者的成功治疗率差异无统计学意义(P>0.05);37例(88.10%)患者因主观因素(失访/自行停药/返乡/退组)导致未成功治疗,5例(11.90%)患者因非主观因素(死亡/不良反应停药/转耐多药)导致未成功治疗。在非主观因素或主观因素导致未成功治疗方面,不同性别、户籍、治疗方案(含Lfx与未含Lfx)患者的差异无统计学意义(P>0.05)。结论深圳市Hr-TB患者治疗方案中是否含Lfx治疗成功率差异无统计学意义,患者失访、自行停药、退组等主观因素是导致Hr-TB患者未成功治疗的主要原因,结合当前情况优化防控措施,可望取得更好的治疗效果。 Objective To analyse the treatment outcomes of isoniazid-resistant tuberculosis(Hr-TB)in Shenzhen,and MethodsData of registration records of Hr-TB patients which were enrolled in Shenzhen’s drug-resistant TB project for treatment from January 2016 to January 2019,and the treatment outcome of patients with completed treatment course of Hr-TB patients and the reasons for unsuccessful treatment before February 2020 were analyzed.ResultsIn 144 Hr-TB patients treated with the project,102 cases were successful treatment(70.83%),42 cases without successful treatment(29.17%).There were no significant difference in different gender,household registration and the successful treatment rate between the treatment regimen containing Levofloxacin(Lfx)and without Lfx(P>0.05).37 cases with treatment unsuccessfully(88.10%)were due to the subjective factors(loss of follow-up/self discontinuation/return home/drop out),and 5 cases with treatment unsuccessfully(11.90%)were due to non-subjective factors(death/withdrawal for the adverse reactions/convert to multidrug resistance).In terms of non-subjective factors or subjective factors leading to unsuccessful treatment,there were no statistically significant differences between patients of different genders,household registration and treatment regimen(including Lfx and without Lfx)(P>0.05).ConclusionLfx in the therapeutic regimen of Hr-TB patients had no difference in the rate of successful treatment in Shenzhen,loss of follow-up,self-discontinuation and drop out were the main reasons of treatment unsuccessfully in patients with Hr-TB in Shenzhen.To optimize the appropriate control measures for them could achieve better therapeutic effect.
作者 卢春容 吴清芳 李明珍 邹小飞 李晓定 吴珊 谭卫国 LU Chunrong;WU Qingfang;LI Mingzhen;ZOU Xiaofei;LI Xiaoding;WU Shan;TAN Weiguo(Institute for the Prevention and Treatment of Lung Diseases,Center for Chronic Disease of Shenzhen,ShenZhen,Guangdong 518020,China)
出处 《中国热带医学》 CAS 2020年第12期1130-1133,共4页 China Tropical Medicine
基金 “十三五”国家重大科技专项(No.2018ZX10715004-002) 深圳市科技创新计划基础研究项目(No.JCYJ20180306170526435) 深圳市医疗卫生三名工程(No.SZSM201611030)。
关键词 结核 异烟肼耐药 治疗 转归 深圳市 Tuberculosis,pulmonary Isoniazid-resistance treatment outcome Shenzhen
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