摘要
目的观察加味凉膈散辅助治疗儿童口腔糜烂心脾积热证的临床疗效。方法选取2019年1—12月宁波市北仑区人民医院口腔科门诊收治的口腔糜烂心脾积热证患儿100例,按随机数字表法分为治疗组和对照组,各50例。对照组给予常规西医对症治疗,治疗组在对照组治疗方法的基础上给予加味凉膈散治疗,2组均以1个月为1个疗程,连续治疗1个疗程后统计临床疗效,比较治疗前后症状体征评分、血清内皮素-1(ET-1)、血栓调节蛋白(TM)和C-反应蛋白(CRP)以及T淋巴细胞亚群的变化。结果治疗组总有效率为92%(46/50),对照组为76%(38/50),2组比较,差异有统计学意义(P<0.05)。治疗前,2组症状体征评分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组症状体征评分均较同组治疗前明显降低(P<0.05),且治疗组降低更显著(P<0.05)。治疗前,2组血清ET-1、TM、CRP水平比较,差异无统计学意义(P>0.05),具有可比性。治疗后,对照组上述指标水平无明显变化,与同组治疗前比较,差异无统计学意义(P>0.05);治疗组上述指标水平较同组治疗前明显降低,且与对照组治疗后比较,差异均有统计学意义(P<0.05)。治疗前,2组T淋巴细胞CD4+、CD8+、CD4+/CD8+水平比较,差异均无统计学意义(P>0.05),具有可比性。治疗后,对照组上述指标水平无明显变化,与同组治疗前比较,差异无统计学意义(P>0.05);治疗组CD4+、CD4+/CD8+水平较同组治疗前上升(P<0.05),CD8+水平降低(P<0.05),且与对照组治疗后比较,差异有统计学意义(P<0.05)。结论加味凉膈散辅助治疗儿童口腔糜烂心脾积热证,不仅能改善患儿临床症状及体征,减轻炎性反应,而且保护血管内皮,提高机体免疫力,疗效显著,值得临床推广应用。
Objective To observe the clinical efficacy of Jiawei Liangge San(加味凉膈散) in adjuvant treatment of oral erosion in children with heart and spleen heat accumulation syndrome.Methods From January to December 2019,100 cases of oral erosion in children with heart and spleen heat accumulation syndrome admitted into outpatient service in stomatology department of Ningbo Beilun District The People’s Hospital were chosen and divided into treatment group and control group according to the random number table method,with 50 cases in each.The control group was given routine Western medicine symptomatic treatment,on this basis,the treatment group was given Jiawei Liangge San.One month was taken as a course of treatment in the 2 groups.After one course of continuous treatment,we kept statistics about the clinical efficacy and compared the scores of symptoms and signs,serum endothelin-1(ET-1),thrombomodulin(TM),C-reactive protein(CRP) and compared the changes of T lymphocyte group before and after treatment.Results The total effective rate in the treatment group was 92%(46/50),that in the control group was 76%(38/50),and the difference between the 2 groups was statistically significant(P<0.05).Before treatment,the difference was not statistically significant in the scores of symptoms and signs between the 2 groups(P>0.05),and they were comparable. After treatment,the scores of symptoms and signs in the 2 groups significantly decreased compared with those in the same group before treatment(P<0.05),moreover,the treatment group decreased more significantly(P<0.05).Before treatment,the difference was not statistically significant in serum levels of ET-1,TM and CRP between the 2 groups(P>0.05),and they were comparable.After treatment,the above mentioned levels in the control group had no significant change,and the difference was not statistically significant compared with the same group before treatment,and the above-mentioned levels in the treatment group significantly decreased compared with those in the same group befo
作者
杨赛燕
刘瑜
YANG Saiyan;LIU Yu(Department of Stomatology,Ningbo Beilun District The People’s Hospital,Ningbo,Zhejiang,315800,China;Department of Pediatrics,Ningbo Beilun District The People’s Hospital,Ningbo,Zhejiang,315800,China)
出处
《中医儿科杂志》
2020年第6期64-67,共4页
Journal of Pediatrics of Traditional Chinese Medicine
关键词
口腔糜烂
儿童
加味凉膈散
心脾积热证
临床观察
oral erosion
children
Jiawei Liangge San(加味凉膈散)
heart and spleen heat accumulation syn-drome
clinical observation
