摘要
随着生活环境改变和社会压力增加,男性精液质量逐步下降,男性不育症发病率逐年上升,愈来愈受到人们关注。精液分析是目前诊断男性不育症的首选检查,但无法明确与男性不育症相关的精液代谢改变及其相关机制,且临床上尚存在部分不育症患者表现出正常的精液分析结果。代谢组学的出现有希望弥补精液分析的这些不足。代谢组学通过对样本中小分子代谢产物进行定性和定量分析,寻找疾病发生发展的生物标志物,为疾病诊疗提供新方法。近年来,各国学者利用代谢组学对不育男性的血清、精浆等样本进行研究,发现了多种可能与男性不育症相关的生物标志物,涉及氧化应激、能量代谢、信号转导中的多种通路。本文就近年来代谢组学在无精子症、少精子症、弱精子症、畸形精子症及不明原因男性不育症中的研究进展作一综述,以期为不育症的临床诊疗提供新思路。
With the change of living environment and the increase of social pressure,the quality of male semen is gradually declining,and the incidence of male infertility is increasing year by year,which attracts more and more attention.At present,semen analysis is the first choice for diagnosis of male infertility,but it is impossible to clarify the changes in semen metabolism associated with male infertility and its related mechanisms,and there are still some infertile patients who show normal semen parameters.The emergence of metabolomics is expected to compensate for these deficiencies in semen analysis.Metabolomics can provide biomarkers for diseases by qualitative and quantitative analysis of small molecular metabolites in different samples.In recent years,scholars in various countries have used metabolomics to study the serum,seminal plasma and other samples of infertile men.Many biomarkers related to male infertility have been found,involving multiple metabolic pathways in oxidative stress,energy metabolism and signal transduction.In this paper,the research progress of metabonomics in azoospermia,oligozoospermia,asthenospermia,teratospermia and unexplained male infertility is reviewed,in order to provide new ideas for clinical diagnosis and treatment of infertility.
作者
吴华
王晖
钱云
Wu Hua;Wang Hui;Qian Yun(Clinical Center of Reproductive Medicine,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China;Department of Histology and Embryology,Basic Medical College,State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing 211166,China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2020年第10期864-870,共7页
Chinese Journal of Reproduction and Contraception
基金
国家自然科学基金(81774075)。
关键词
男性不育症
代谢组学
代谢紊乱
生物标志物
潜在机制
Male infertility
Metabolomics
Metabolic disorders
Biomarkers
Underlying mechanisms
