摘要
作为人体微生物菌群中真菌菌群的一个重要组成部分,念珠菌通常定植于人体的众多生态位,在免疫系统功能正常的健康人群中与宿主保持共生状态。为适应宿主体内复杂多变的环境,拮抗宿主免疫系统的攻击,以及应对其他微生物菌群的竞争等诸多生存压力,念珠菌进化出一系列极为有效的应对机制以维持其在宿主体内的共生。本文总结了念珠菌通过形态转换、环境适应、免疫调节以及与其他微生物菌群相互作用等策略应对宿主环境生存压力的分子机制,重点阐述了念珠菌、宿主免疫系统以及微生物菌群三者之间的相互作用和相互平衡对于念珠菌实现成功定植和共生的重要意义。
As a major component of the human mycobiota,Candida species regularly colonize diverse niches of the human body,being commensals in the healthy,immunocompetent individuals.To adapt the complex host environment,resist the attack from the host immunity and compete with other microbes,Candida spp.have evolved a range of sophisticated strategies to maintain their commensal life in the host.In this review,we summarize recent research progresses about the mechanisms by which Candida species cope with the host stresses,including those involving morphological changes,environmental adaptation,immune regulation and interactions with other microorganisms,and delineate the importance of balancing mutuality and interaction between Candida spp.,host immune system and microbiome in sustaining the colonization and commensalism of these fungi.
作者
姜彤
陈昌斌
JIANG Tong;CHEN Chang-Bin(The Center for Microbes,Development and Health,CAS Key Laboratory of Molecular Virology and Immunology,Institut Pasteur of Shanghai,Chinese Academy of Sciences,Shanghai 200031,China;University of Chinese Academy of Sciences,Beijing 100049,China)
出处
《菌物学报》
CAS
CSCD
北大核心
2020年第11期2131-2148,共18页
Mycosystema
关键词
念珠菌
共生
微生物菌群
免疫调节
Candida species
commensalism
microbiome
immune regulation
