摘要
目的探讨盐酸安罗替尼胶囊治疗晚期非小细胞肺癌的临床效果。方法选取2016年5月~2018年5月深圳市宝安区人民医院收治的86例晚期非小细胞肺癌患者作为研究对象,采用随机数字表法将其分为参照组和研讨组,每组各43例。参照组患者采用安慰剂治疗,研讨组患者采用盐酸安罗替尼胶囊治疗。比较两组患者的肿瘤进展或死亡时间(PFS)、总生存时间(OS)、临床疗效、不良事件(AEs)总发生率等生存情况指标。结果研讨组患者的PFS与OS均长于参照组,差异有统计学意义(P<0.05)。研讨组患者的临床疗效优于参照组,差异有统计学意义(P<0.05)。两组患者的AEs总发生率比较,差异无统计学意义(P>0.05)。结论盐酸安罗替尼胶囊治疗晚期非小细胞肺癌具有较好的临床效果,可以有效延长患者的无进展生存时间,同时具有良好的耐受性,但在安全性方面,仍需进一步扩大研究范围评估。
Objective To investigate the clinical effect of Anlotinib Hydrochloride Capsules in the treatment of advanced non-small cell lung cancer.Methods A total of 86 patients with advanced non-small cell lung cancer who admitted to Bao′an District People′s Hospital of Shenzhen City from May 2016 to May 2018 were selected as the research objects and divided into the control group and the study group by random number table method,with 43 cases in each group.The control group was treated with placebo,while the study group was treated with Anlotinib Hydrochloride Capsules.The time of tumor progression or death(PFS),total survival time(OS),clinical effect and total incidence of adverse events(AEs)were compared between the two groups.Results The PFS and OS in the study group were longer than those in the control group,and the differences were statistically significant(P<0.05).The clinical effect of the study group was better than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in total incidence of AEs between the two groups(P>0.05).Conclusion The clinical effect of Anlotinib Hydrochloride Capsules in the treatment of advanced non-small cell lung cancer is better,it can effectively extend the patients′progression-free survival time,and has good tolerance,but in terms of safety,evaluation of the scope of the study still needs to be further expanded.
作者
魏照光
成彦霖
王长青
何爱军
WEI Zhao-guang;CHENG Yan-lin;WANG Chang-qing;HE Ai-jun(Department of Oncology,Bao′an District People′s Hospital of Shenzhen City,Guangdong Province,Shenzhen518101,China;Department of Gastroenterology,Bao′an District People′s Hospital of Shenzhen City,Guangdong Province,Shenzhen518101,China)
出处
《中国当代医药》
2020年第34期111-113,共3页
China Modern Medicine
关键词
盐酸安罗替尼胶囊
晚期
非小细胞肺癌
临床效果
Antinib Hydrochloride Capsules
Advanced
Non-small cell lung cancer
Clinical effect
