摘要
以I2为催化剂,原甲酸三乙酯、芳(杂环)胺和亚磷酸二乙酯为原料,室温无溶剂条件下,一锅合成了系列芳(杂环)胺亚甲基双膦酸四乙酯,收率96%~99%。当I2物质的量分数为5%时,产物收率最高。本方法底物适用范围广,操作简单。I2作为催化剂,安全高效。
A number of aryl/heteroaryl aminomethylene bisphosphonates were synthesized by one-pot reaction of diverse aryl/heteroaryl amines with diethyl phosphite and triethyl orthoformate in the presence of I 2 under solvent free conditions.The product yields are 96%~99%.When the molar fraction of I 2 is 5%,the product yield is the highest.The procedure is simple and the substrate scope is large.I 2 is safe and very efficient as the catalyst.
作者
张宝华
史兰香
ZHANG Baohua;SHI Lanxiang(College of Chemical Engineering,Shijiazhuang University,Shijiazhaung,Hebei 050035,China)
出处
《应用化学》
CAS
CSCD
北大核心
2020年第8期877-882,共6页
Chinese Journal of Applied Chemistry
基金
河北省科技支撑项目(18271404D)资助。
