摘要
背景:聚醚酮酮具有优良的生物相容性,被广泛用于脊柱、关节及口腔颌面外科等生物医学领域中。目的:归纳和总结目前聚醚酮酮的合成及其在医学应用方面的研究进展。方法:检索PubMed、Web of Science和CNKI数据库等收录的有关聚醚酮酮合成发展及其在生物医学领域中应用的文章,英文检索词为“polyetherketoneketone,synthesis,scaffold material,implant,tissue engineering,biocompatibility”,中文检索词为“聚醚酮酮,合成,支架材料,植入物,组织工程,生物相容性”。根据纳入与排除标准对所有文章进行初筛后,保留相关性较高的文章进行综述。结果与结论:近年来随着医工结合的兴起,聚醚酮酮及其复合物逐渐应用到骨科、口腔颌面外科等生物医学领域。在骨科方面,经过不同物理化学改性的聚醚酮酮及其复合物不仅可以保持与人体骨骼相似的弹性模量、提升硬度,还可以改善其生物相容性、增加其抑菌性能、促进骨整合等。在口腔颌面外科方面,可用作种植牙基体、框架、可摘局部义齿的卡环等,聚醚酮酮不仅可以保持良好的美学优势,同时可以拥有良好的抗疲劳性及保持力,与口腔内的黏合系统能保证充分的黏合能力,因此聚醚酮酮作为口腔科修复材料的应用潜力巨大。对聚醚酮酮的改性及其复合物更深层次的研究仍然是一大热点,通过不断提升材料的性能,进行更多的体内外实验来证实聚醚酮酮作为骨科及口腔颌面外科植入物材料的优越性,进行临床转化,将会拥有更好的前景。
BACKGROUND:Polyetherketoneketone has excellent biocompatibility and is widely used in biomedical fields such as spine,joint and oral and maxillofacial surgery.OBJECTIVE:To summarize the synthesis of polyetherketoneketone and its research progress in medical applications.METHODS:PubMed,Web of Science and CNKI databases were searched for the articles concerning about the synthesis and development of polyetherketoneketone and their applications in the field of biomedicine with the search terms of“polyetherketoneketone,synthesis,scaffold material,implant,tissue engineering,biocompatibility”in English and Chinese,respectively.After initial screening of all articles according to inclusion and exclusion criteria,articles with higher relevance were included for review.RESULTS AND CONCLUSION:In recent years,with the rise of the combination of medical and engineering,polyetherketoneketone and its composites have been gradually applied to the fields of orthopedics,oral and maxillofacial surgery.In orthopedics,polyetherketoneketone and its compounds modified with different physical and chemical properties can not only maintain the elastic modulus similar to human bones,increase the hardness,but also improve its biocompatibility,increase its antibacterial properties,and promote osseointegration.In oral and maxillofacial surgery,it can be used as a dental implant matrix,frame,and snap ring for removable partial dentures.Polyetherketoneketone can not only maintain good aesthetic advantages,but also has good fatigue resistance and retention,which is comparable to the oral cavity.The bonding system can ensure sufficient bonding ability,so polyetherketoneketone has great potential as a dental restoration material.In-depth research on the modification of polyetherketoneketone and its compound is still a hot topic.Through continuous improvement of the performance of the material,more in vivo and in vitro experiments have been carried out to confirm the superiority of polyetherketoneketone as an implant material for orthopedics a
作者
闻志靖
顾鹏真
贺西京
李家良
王一斌
王逸群
Wen Zhijing;Gu Pengzhen;He Xijing;Li Jialiang;Wang Yibin;Wang Yiqun(Department of Orthopedics,The Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,Shaanxi Province,China;Xi’an International Medical Center Hospital,Xi’an 710100,Shaanxi Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2021年第22期3603-3608,共6页
Chinese Journal of Tissue Engineering Research
基金
中央高校建设世界一流大学(学科)和特色发展引导专项资金(PY3A023),项目负责人:贺西京。
关键词
骨
材料
聚醚酮酮
植入物
支架材料
生物相容性
组织工程
研究进展
综述
bone
material
polyetherketoneketone
implant
scaffold material
biocompatibility
tissue engineering
research progress
review
