摘要
目的:探究心力衰竭(心衰)患者血清胱抑素C(cys C)水平与阵发性房颤复发的关系。方法:选取2017年6月-2018年9月于本院就诊的伴阵发性房颤的心衰患者60例,复律后,统计患者房颤复发的例数、次数及首次复发时间,并根据患者是否复发房颤分为复发组与未复发组。分析两组患者的影响因素,两组入院时、复律后7、21、30、60、90、180 d血清cys C水平,分析cys C水平与房颤复发的相关性及房颤复发的影响因素。结果:复律后共有21例患者复发,复发率为35%(21/60);首次复发时间为复律后(32.81±2.09)d,平均复发次数为(2.13±0.46)次。复发组年龄>75岁、有高血压史及吸烟史的比例均高于未复发组(P<0.05)。入院时与复律后7 d,两组cys C水平比较,差异均无统计学意义(P>0.05);复律后21 d,两组cys C水平均低于入院时(P<0.05),且组间比较差异均无统计学意义(P>0.05);复律后30 d,复发组cys C水平开始上升,至复律后180 d已上升至入院时水平(P>0.05)。未复发组复律后21~180 d的cys C水平均低于入院时(P<0.05),且复律后180 d时cys C水平与21 d时相近,无明显变化(P>0.05)。复律后60、90、180 d,未复发组cys C水平均低于复发组(P<0.05)。房颤复发与血清cys C和年龄呈正相关(r=0.211、0.197,P=0.004、0.024)。cys C水平和年龄>75岁是房颤复发的独立危险因素(OR=6.626、3.127,P=0.005、0.018)。结论:患者年龄>75岁与血清cys C水平是房颤复发的危险因素,并且血清cys C水平与房颤复发呈正相关。
Objective:To investigate the relationship between serum cystatin C(cys C)levels and recurrence of paroxysmal atrial fibrillation in patients with heart failure.Method:A total of 60 heart failure patients with paroxysmal atrial fibrillation visited in our hospital from June 2017 to September 2018 were selected.After cardioversion,the number of cases,frequency and time of the first recurrence of atrial fibrillation were counted,and the patients were divided into the recurrent group and the non-recurrent group according to whether the patients had recurrent atrial fibrillation.The general data of the two groups were compared.Serum cys C levels were compared between the two groups at admission and at 7,21,30,60,90 and 180 d after cardioversion.The correlation between cys C level and recurrence of atrial fibrillation and the influencing factors of recurrence of atrial fibrillation were analyzed.Result:A total of 21 patients had recurrence after cardioversion.The first time of recurrence was(32.81±2.09)d after cardioversion,and the average number of recurrence was(2.13±0.46)times.The proportion of>75 years old,history of hypertension and history of smoking in the recurrent group were higher than those in the non-recurrent group(P<0.05).At admission and 7 d after cardioversion,There was no statistically significant difference in cys C level between the two groups(P>0.05).At 21 d after cardioversion,the cys C level in both groups were lower than those at admission(P<0.05),the difference between the two groups was not statistically significant(P>0.05).At 30 d after cardioversion,the cys C level in the recurrent group began to rise,and rose to the admission level at 180 d after cardioversion(P>0.05).The cys C level at 21-180 d after cardioversion in the non-recurrent group were lower than those at admission(P<0.05),and the cys C level at 180 d after cardioversion was similar to that at 21 d after cardioversion,without significant change(P>0.05).At 60,90 and 180 d after cardioversion,the level of cys C in the non-recurren
作者
罗刚
LUO Gang(People’s Hospital of Ganzhou City,Ganzhou 341000,China)
出处
《中国医学创新》
CAS
2020年第34期141-144,共4页
Medical Innovation of China
基金
赣州市指导性科技计划项目(GZ2018ZSF266)。
关键词
心衰
胱抑素C
阵发性房颤
复发
Heart failure
Cystatin C
Paroxysmal atrial fibrillation
