摘要
目的探讨温针灸对幽门螺杆菌(Hp)阳性A型慢性萎缩性胃炎(CAG)患者血清胃泌素(Gas)水平及临床疗效的影响。方法选择90例Hp阳性A型CAG患者为研究对象,按随机数字表分为对照组(45例,常规药物治疗)、研究组(45例,常规药物治疗+温针灸治疗)。比较两组治疗前后内源性活性物质Gas水平、临床症状及生存质量的变化,评估临床疗效及安全性。结果两组治疗后临床症状评分及Gas水平均低于同组治疗前,组内差异(P<0.01);治疗后研究组临床症状评分及Gas水平低于同期对照组,组间差异(P<0.01)。两组治疗后躯体疼痛(BP)、生命活力(VT)、生理功能(PF)、健康总体自评(GH)评分较同组治疗前增加,组内差异(P<0.01);两组治疗前后生理角色(RP)、心理健康(MH)、社会功能(SF)、情感角色(RE)评分无明显改变,组内差异(P>0.05);研究组治疗后BP、PF、VT、GH评分高于同期对照组,组间差异(P<0.05)。治疗后对照组Hp根除率88.9%(40/45),研究组93.3%(42/45),组间差异(P>0.05)。整个治疗过程中,研究组无不良事件发生;对照组出现1例恶心,余未见明显不适;组间间差异(P>0.05)。结论温针灸治疗Hp阳性A型CAG患者安全可靠,可进一步改善患者临床症状及部分生活质量;其机制可能与调节Gas水平及提高根除Hp相关。
Objective To investigate the effect of warm acupuncture on serum gastrin(Gas)level and clinical efficacy in patients with Helicobacter pylori(HP)positive type A chronic atrophic gastritis(CAG).Methods 90 cases of CAG patients with HP positive type A were selected and randomly divided into control group(45 cases,conventional drug treatment)and study group(45 cases,conventional drug treatment and warm acupuncture treatment).The levels of endogenous active substance gas,clinical symptoms and quality of life were compared between the two groups before and after treatment,and the clinical efficacy and safety were evaluated.Results After treatment,the clinical symptom score and gas level in the two groups were lower than those before treatment in the same group(P<0.01),the clinical symptom score and gas level in the study group were lower than those in the control group at the same period(P<0.01).After treatment,the scores of body pain(BP),vitality(VT),physiological function(PF)and overall health selfassessment(GH)in the two groups were increased compared with those before treatment in the same group(P<0.01);the scores of physiological role(RP),mental health(MH),social function(SF)and emotional role(RE)of the two groups had no significant changes before and after treatment,and the intra group difference was(P>0.05);BP,PF,VT,GH scores of the study group were higher than those of the control group at the same period(P<0.05).After treatment,the HP eradication rate of the control group was 88.9%(40/45),and that of the study group was 93.3%(42/45),with the difference between the two groups(P>0.05).During the whole treatment process,no adverse events occurred in the study group;1 case of nausea occurred in the control group,and no obvious discomfort was found in the rest;the difference between the two groups(P>0.05).Conclusion Warm acupuncture and moxibustion is safe and reliable in the treatment of HP positive CAG patients with type a CAG,which can further improve the clinical symptoms and some quality of life.The mechanism
作者
李丹
常小荣
LI Dan;CHANG Xiaorong(Liuyang Hospital of traditional Chinese Medicine,Hunan Liuyang 410300,China;Hunan University of Chinese Medicine,Hunan Changsha 410208,China)
出处
《中医药临床杂志》
2020年第11期2133-2136,共4页
Clinical Journal of Traditional Chinese Medicine
基金
国家重点基础研究发展计划(973计划)2015CB554502,艾灸与针刺作用特点、效应响应异同的基础与临床研究。
关键词
温针灸
A型慢性萎缩性胃炎
血清胃泌素
疗效机制
Warm acupuncture
Type A chronic atrophic gastritis
Serum gastrin
Therapeutic mechanism
