摘要
目的:研究糖尿病患者的眼轴长度与糖尿病性视网膜病变(diabetic retinopathy,DR)的相关性,并分析其临床意义。方法:按眼轴长度将60例(120眼)2型糖尿病患者分为3组:眼轴长度≤24 mm(62眼)、>24~<26 mm(41眼)、≥26 mm(17眼)。采用国际标准对数视力表检查视力;裂隙灯显微镜检查眼前节,排除高眼压、浅前房后,予复方托吡卡胺滴眼液散瞳,采用裂隙灯显微镜下前置镜和荧光素钠眼底血管造影术(fluorescein fundus angiography,FFA)检查眼底,A型超声波测量眼轴长度。根据患者DR的严重程度分为无DR组(no diabetic retinopathy,NDR)、非增生型DR组(non-proliferative diabetic retinopathy,NPDR)、增生型DR组(proliferative diabetic retinopathy,PDR),进行统计学分析。结果:患眼眼轴越长,DR病变程度越轻,二者之间存在等级相关,且为负相关(Kendall检验P=0.027,r=-0.331;Spearman检验P=0.014,r=-0.327)。眼轴>26 mm组与其他两组患者的PDR发生率之间差异有统计学意义(χ^2=35.607,P=0.008)。结论:患者眼轴越长,DR病变程度相对较轻,眼轴长是PDR的保护性因素。
Objective:To evaluate the relationship between axial length and diabetic retinopathy(DR),and explore its clinical significance.Methods:According to axial length,there are sixty type-2 diabetic patients(120 eyes)were divided into three groups:shorter than 24 mm(62 eyes),between 24 mm and 26 mm(41 eyes),longer than 26 mm(17eyes).The anterior segment was examined by slit lamp microscope.Visual acuity was examined by international standard visual acuity chart.After eliminating high intraocular pressure and shallow anterior chamber,compound tropicamide eye drops for mydriasis.Fundus was examined by slit lamp microscope and fluorescein fundus angiography.Axial length was measured by A-scan ultrasound.The patients were graded into three groups by the severity of DR:no diabetic retinopathy(NDR),none proliferative diabetic retinopathy(NPDR)and proliferative diabetic retinopathy(PDR),made a statistical analysis.Results:With the axial length increased,the severity of DR reduced,showed the negative ranked relation,there were statistical differences(Kendall test,P=0.027,r=-0.331;Spearman test P=0.014,r=-0.327).In axial length 26 mm group,the incidence of PDR was less than the other two groups,there were statistical differences(χ^2=35.607,P=0.008).Conclusion:Axial length was longer,the severity of DR was mild.Longer axial length is protective factor of PDR.
作者
蒋晓冲
杨卫丹
成铃
陈晨
JIANG Xiaochong;YANG Weidan;CHENG Ling;CHEN Chen(Department of Ophthalmology,Nantong Tongzhou People′s Hospital,Jiangsu Province,Nantong 226300)
出处
《南通大学学报（医学版）》
2020年第5期455-457,共3页
Journal of Nantong University(Medical sciences)
基金
南通市卫生和计划生育委员会科研立项课题(WKZD2018004)。
