摘要
目的探讨胰岛素强化治疗对脑梗死急性期2型糖尿病患者的应用效果。方法84例脑梗死急性期2型糖尿病患者,以随机数字表法分为对照组与观察组,各42例。对照组采取餐前注射短、中效胰岛素维持血糖,观察组采取胰岛素强化治疗方案维持血糖。对比两组患者治疗前后昏迷情况及神经功能缺损改善情况。结果治疗前,两组患者格拉斯哥昏迷指数(GCS)评分对比,差异无统计学意义(P>0.05);治疗3、7、14 d,观察组的GCS评分均高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者美国国立卫生研究院卒中量表(NIHSS)评分对比,差异无统计学意义(P>0.05);治疗14 d,观察组患者NIHSS评分(11.36±3.85)分低于对照组的(13.58±4.22)分,差异有统计学意义(P<0.05)。结论采用胰岛素强化治疗控制脑梗死急性期2型糖尿病患者的血糖,效果较常规口服或注射短、中效胰岛素的效果更为理想,能将患者的血糖维持在更理想区间,同时对于患者神经功能的改善也有一定的助推作用。
Objective To discuss the practical effect of intensive insulin therapy on type 2 diabetes mellitus in patients with acute cerebral infarction.Methods A total of 84 cases of type 2 diabetes mellitus in acute stage of cerebral infarction were divided into control group and observation group according to random numerical table,with 42 cases in each group.The control group took pre-meal injections of short and mediumacting insulin to maintain blood glucose,and the observation group took intensive insulin therapy to maintain blood glucose.The coma and neurological deficit improvement before and after treatment were compared between the two groups.Results Before treatment,there was no statistically significant difference in Glasgow coma scale(GCS)score between the two groups(P>0.05).3,7 and 14 d after treatment,GCS score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in National Institutes of Health stroke scale(NIHSS)score between the two groups(P>0.05).14 d after treatment,NIHSS score(11.36±3.85)points of the observation group was lower than(13.58±4.22)points of the control group,and the difference was statistically significant(P<0.05).Conclusion The effect of intensive insulin therapy on the control of blood glucose of patients with type 2 diabetes mellitus in acute stage of cerebral infarction is better than that of conventional oral administration or injection of short and medium acting insulin.It can maintain the blood glucose of patients in a more ideal range,and also has a certain role in promoting the improvement of neurological function of patients.
作者
卢钰萱
吴晓丹
LU Yu-xuan;WU Xiao-dan(Department of Endocrinology,Rheumatism and Immunology,Chaozhou People’s Hospital,Chaozhou 521000,China)
出处
《中国现代药物应用》
2020年第22期84-86,共3页
Chinese Journal of Modern Drug Application
关键词
脑梗死急性期
血糖控制
胰岛素强化治疗
Acute cerebral infarction
Blood glucose control
Intensive insulin therapy
