摘要
硒是人体所需的重要微量元素,与人体健康和疾病密切相关。近年来,硒及其硒化合物对肿瘤细胞具有高效的选择性细胞毒性得到广泛关注。亚硒酸盐作为自然界中最常见及研究最多的无机硒化物,通常被认为通过充当促氧化剂来杀伤肿瘤细胞。亚硒酸盐能与细胞内的硫醇反应介导活性氧簇产生,氧化参与代谢、转录、信号转导等相关蛋白中的巯基,改变其生物活性进而抑制肿瘤细胞增殖,但其发挥抗癌作用的机制远不止这些。研究发现亚硒酸盐可通过抑制相关酶活性及调控代谢基因干扰肿瘤营养代谢,激活内源及外源性凋亡通路,调控抑癌或促癌基因表观遗传修饰,转化为内源性硒纳米颗粒介导细胞毒性,刺激免疫细胞分裂活化并协助识别肿瘤抗原等机制发挥肿瘤抑制作用。进一步加强对亚硒酸盐抗肿瘤作用的研究和认识,既能为临床新药开发提供一定的证据,又能为临床医师提供新的治疗思路,对提高肿瘤治疗效果具有重要意义。这篇综述旨在总结亚硒酸盐在抗肿瘤方面的作用及其机制的研究进展。
Selenium is an important trace element required by the human body and is closely related to human health and diseases.In recent years,selenium and its compounds have attracted widespread attention for their highly selective cytotoxicity against tumor cells.Selenite,as the most common and studied inorganic selenide in nature,is generally regarded as a pro-oxidant to kill tumor cells.Selenite can react with intracellular thiols to mediate the production of reactive oxygen species,oxidize sulfhydryl groups in related proteins involved in metabolism,transcription,signal transduction,and change its biological activity to inhibit tumor cell proliferation,but its effects of anti-cancer are far more than that.Studies have reported that selenite can regulate these mechanisms to play a role in tumor suppression:inhibiting related enzyme activities and regulating metabolic genes to interfere with tumor nutrient metabolism,activating endogenous and exogenous apoptosis pathways,regulating the epigenetic modification of tumor suppressor genes or oncogenes,being converted into endogenous selenium nanoparticles to mediate cytotoxicity,stimulating immune cells division and activation and assisting in identifying tumor antigens,etc.Further strengthening the research and understanding of the anti-tumor effect of selenite can not only provide certain evidence for the development of new clinical drugs,but also provide new treatment ideas for clinical oncologists,which is of great significance for improving the effect of tumor treatment.This review aims to summarize the research progress of the antitumor effects and mechanisms of selenite.
作者
李雨珊
周岚
Li Yushan;Zhou Lan(Department of Clinical Nutrition,The Third Affiliated Hospital of Kunming Medical University,Kunming 650118,Yunnan,China)
出处
《肿瘤代谢与营养电子杂志》
2020年第4期490-496,共7页
Electronic Journal of Metabolism and Nutrition of Cancer
基金
昆明医科大学研究生创新基金项目(2020S213)
昆明医科大学应用基础研究联合专项面上项目(202001AY070001-076)。
