摘要
目的观察白芍总苷胶囊联合吲哚美辛片口服治疗结节性红斑的临床疗效及对外周血清C-反应蛋白(CRP)、红细胞沉降率(ESR)水平的影响。方法选取2018年1月至2019年6月于成都市第二人民医院皮肤科门诊收治的结节性红斑患者120例,按照随机数字表法分为治疗组和对照组,每组60例。对照组口服吲哚美辛片、维生素C片,外用成都市第二人民医院院内制剂黄连炉甘石洗剂;治疗组口服白芍总苷胶囊、吲哚美辛片、维生素C片,外用黄连炉甘石洗剂;2周为1个疗程,连续治疗2个疗程,每7 d随访1次。治疗结束后评价两组患者临床疗效,并比较CRP及ESR水平。治疗结束后随访4个月,比较两组患者的复发率。结果治疗组患者总显效率为90.00%,明显高于对照组的71.67%,两组比较差异有统计学意义(P<0.05);与治疗前比较,两组患者治疗后外周血CRP和ESR水平均明显下降(P<0.05);治疗组患者外周血CRP和ESR水平均明显低于对照组,差异有统计学意义(P<0.05);两组患者均未出现严重不良反应,治疗前和治疗结束时查患者血、大小便常规、肝肾功能均未见异常。对照组患者复发率为33.3%,明显高于治疗组的11.4%,两组比较差异有统计学意义(P<0.05)。结论采用白芍总苷胶囊联合吲哚美辛片口服治疗结节性红斑临床疗效满意,复发率低,值得临床推广。
Objective To observe the clinical efficacy of total glucosides of paeony capsule combined with indomethacin tablet in the treatment of erythema nodosum and its influence on the levels of serum C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)in peripheral blood.Methods A total of 120 patients with erythema nodosum treated in the dermatology clinic of Chengdu Second People's Hospital from January 2018 to June 2019 were selected and divided into treatment group and control group according to random number table method,with 60 patients in each group.In the control group,indomethacin tablets and vitamin C tablets were taken orally,and coptis calamine lotion produced by Chengdu Second People's Hospital was applied externally.In the treatment group,total glucosides of paeony capsules,indomethacin tablets and vitamin C tablets were taken orally,and coptis calamine lotion was applied externally.2 weeks for 1 course of treatment,continuous treatment for 2 courses,follow-up every 7 days.After treatment,the clinical efficacy of the two groups was evaluated,and the levels of CRP and ESR were compared between the two groups.Patients were followed up for 4 months after treatment to compare the recurrence rate between the two groups.Results The total effective rate of the treatment group was 90.00%,which was significantly higher than 71.67%of the control group,and the difference between the two groups was statistically significant(P<0.05).Compared with before treatment,the levels of CRP and ESR in peripheral blood of patients in both groups were significantly decreased after treatment(P<0.05).The levels of CRP and ESR in peripheral blood of patients in the treatment group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).No serious adverse reactions occurred in the two groups.And no abnormalities were observed in blood,urine and feces,liver function and renal function before and after treatment.The recurrence rate of the control group was 33.3%,which
作者
吴波
倪瑶
Wu Bo;Ni Yao(Dermatology Department, Chengdu Second People's Hospital, Chengdu 610017, China)
出处
《成都医学院学报》
CAS
2020年第6期729-732,共4页
Journal of Chengdu Medical College
关键词
结节性红斑
白芍总苷
吲哚美辛
疗效
复发率
Erythema nodosum
Total glucosides of paeony
Indomethacin
Curative effect
Recurrence rate
