摘要
目的探究以肾上腺髓质素前体中段肽(MR-proADM)水平为指导对重症监护室(ICU)脓毒症患者抗菌药物治疗效果的影响。方法设计前瞻性随机对照研究,选取该院ICU 2018年1月至2019年5月收治的脓毒症患者80例为研究对象,采用随机数字法将患者分为对照组和观察组,每组40例。对照组常规接受抗菌药物治疗,观察组接受MR-proADM指导抗菌药物治疗,观察比较两组治疗疗效。结果观察组患者治疗总有效率为89.19%,对照组治疗总有效率为86.84%,两组差异无统计学意义(P>0.05)。观察组患者ICU住院时间[(13.32±2.11)d]短于对照组[(14.71±2.49)d],差异有统计学意义(P<0.05);观察组患者抗菌药物使用时间[(11.42±1.78)d]低于对照组[(13.23±2.61)d],差异有统计学意义(P<0.05)。观察组患者不良反应发生率(5.00%)低于对照组(22.50%)(P<0.05)。结论脓毒症患者在MR-proADM指导下进行抗菌药物治疗可缩短患者ICU住院时间、抗菌药物使用时间,降低抗菌药物不良反应发生率。
Objective To explore the effect of antimicrobial therapy on patients with sepsis in the intensive care unit(ICU)based on the level of mid-regional proadrenomedullin(MR-proADM)as a guide.Methods A prospective randomized controlled study was designed,80 sepsis patients admitted to the hospital′s ICU from January 2018 to May 2019 were selected as the research objects,and the patients were divided into a control group and an observation group by a random number method,with 40 cases in each group.The control group received routine antibiotic treatment,the observation group received antibiotic treatment guided by MR-proADM and the therapeutic effects of the two groups were observed and compared.Results The total effective rate was 89.19%in the observation group and 86.84%in the control group,the difference between the two groups was not statistically significant(P>0.05).The ICU hospitalization time in the observation group was(13.32±2.11)d,which was significantly shorter than(14.71±2.49)d in the control group,the difference was statistically significant(P<0.05).The use time of antibiotics in the observation group was(11.42±1.78)d,which was lower than(13.23±2.61)d in the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group(5.00%)was significantly lower than that in the control group(22.50%),the difference was statistically significant(P<0.05).Conclusion The antimicrobial therapy of patients with sepsis under the guidance of MR-proADM can shorten the hospitalization time of ICU,the time of antibiotic use,reduce the incidence of adverse reactions of antibiotics.
作者
许永富
阮辉辉
孔铭颢
王建忠
XU Yongfu;RUAN Huihui;KONG Minghao;WANG Jianzhong(Department of Emergency,Tenth People′s Hospital of Tongji University,Shanghai 200072,China)
出处
《国际检验医学杂志》
CAS
2020年第23期2817-2820,共4页
International Journal of Laboratory Medicine
基金
国家自然科学基金项目(81671938)。
