摘要
目的:运用补肾活血利湿法观察独活寄生汤配合消瘀定痛散改善中重度膝骨关节炎(KOA)骨髓水肿(BME)及疼痛的临床疗效。方法:采用随机数字表法将2018年2月至2019年1月就诊于河南中医药大学第一附属医院的60例中重度KOA伴BME患者分为两组,治疗组30例口服独活寄生汤与外敷消瘀定痛散治疗;对照组30例口服扶他林片外用吡罗昔康贴片治疗,均治疗4周。观察对比两组治疗前后BME积分、VAS疼痛评分及临床疗效。结果:两组治疗后BME积分、VAS评分均较治疗前显著改善(P<0.01),且治疗组优于对照组(P<0.05);治疗组总有效率82.76%(24/29),对照组总有效率75.86%(22/29),两组比较差异无统计学意义。结论:补肾活血利湿法能显著改善中重度KOA患者BME程度,减轻膝关节痛觉感受,其减轻KOA疼痛症状的原因可能与缓解膝关节BME存在密切联系。
Objective:To observe the clinical effect of Duhuo Jisheng Decoction combined with Xiaoyu Dingtong Powder on the improvement of bone marrow edema(BME)and pain in moderate and severe knee osteoarthritis(KOA)by tonifying kidney,promoting blood circulation and promoting diuresis method.Methods:A total of 60 patients with moderate and severe KOA and BME in The First Affiliated Hospital of Henan University of Chinese Medicine from February 2018 to January 2019 were divided into two groups by random number table.The treatment group(30 cases)was treated with Duhuo Jisheng Decoction combined with Xiaoyu Dingtong Powder,while the control group(30 cases)was treated with Futalin Tablets and Piroxicam Tablets.The course of the treatment was 4 weeks.The BME score,visual analogue scale(VAS)visual pain score and efficiency evaluation of the two groups were observed and compared before treatment and 4 weeks after treatment.Results:After treatment,the BME score and VAS score of the two groups were significantly improved compared with those before treatment(P<0.01),and the treatment group were significantly better than the control group(P<0.05).The total effective rate of the treatment group was 82.76%(24/29),while that of the control group was 75.86%(22/29)and there was no significant difference between two groups.Conclusion:Tonifying kidney,promoting blood circulation and promoting diuresis method can significantly improve the degree of BME in patients with moderate and severe KOA and relieve the pain sensation of knee joint.The reason may be closely related to the relief of knee joint BME.
作者
孟东方
李慧英
汪利合
李帅鹏
许棋
MENG Dong-fang;LI Hui-ying;WANG Li-he;LI Shuai-peng;XU Qi(Henan University of Chinese Medicine,Zhengzhou 450046,China;The First Affiliated Hospital of Henan University of CM,Zhengzhou 450000,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2020年第11期5898-5901,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
河南省中医药科学研究专项课题(No.2017ZY2044)。
关键词
补肾活血利湿法
中重度膝骨关节炎
骨髓水肿
疼痛
Tonifying kidney,promoting blood circulation and promoting diuresis method
Moderate and severe knee osteoarthritis
Bone marrow edema
Pain
