摘要
目的:观察不同灸疗方案对血透蛋白质能量消耗(PEW)患者氨基酸与肉碱代谢的影响。方法:纳入45例患者,随机分为对照组、调理脾胃组及辨证施灸组,对照组予西医常规治疗,调理脾胃组、辨证施灸组在此基础上分别加"调理脾胃灸法""辨证施灸方案",治疗12周,治疗前后检测氨基酸和酰基肉碱的水平。结果:调理脾胃组、辨证施灸组治疗后丙氨酸(Ala)、亮氨酸(Leu)、缬氨酸(Val)、鸟氨酸(Orn)、苯丙氨酸(Phe)水平明显高于治疗前(P<0.05),在Ala的改善方面,辨证施灸组优于调理脾胃组(P<0.05);对照组、调理脾胃组癸酰肉碱治疗后明显降低(P<0.05),辨证施灸组无显著性差异;对照组3-羟基-十八碳烯酰肉碱治疗后明显下降,调理脾胃组无明显变化,辨证施灸组治疗后显著上升(P<0.05)。结论:灸疗可能通过改善部分氨基酸和肉碱的代谢来改善血透患者PEW,辨证施灸方案效应靶点更多。
Objective:To observe the effects of different moxibustion schemes on amino acid and carnitine metabolism in hemodialysis patients with protein-energy wasting(PEW).Methods:Forty-five hemodialysis patients with PEW were randomly divided into three groups:the harmonizing spleen-stomach group,the individualized moxibustion scheme group and the control group.All groups received conventional western treatment methods.Additionally,the harmonizing spleen-stomach group received moxibustion program to harmonize spleen-stomach,and the individualized moxibustion group received individualized moxibustion.Treatment lasted 12 weeks.Amino acids and carnitines before and after were observed and recorded.Results:The levels of Ala,Leu,Val,Orn and Phe were obviously increased compared with before(P<0.05)in harmonizing spleen-stomach group and individualized moxibustion group.And the level of Ala in individualized moxibustion group was obviously increased compared with harmonizing spleen-stomach group(P<0.05).The levels of C10 were lower than that before treatment in control group and harmonizing spleen-stomach group(P<0.05),and there was no significant difference in individualized moxibustion group.The level of C18:1 OH was obviously decreased compared with before(P<0.05)in control group,but there were no significant difference in harmonizing spleen-stomach group,whereas,it was obviously increased compared with before in the control group individualized moxibustion group(P<0.05).Conclusion:Moxibustion may improve the PEW state of dialysis patients by improving the metabolism of some amino acids and carnitine in blood.The scheme individualized moxibustion seems to have more effective targets.
作者
闫二萍
邱模炎
崔刚
尉万春
柯应水
YAN Er-ping;QIU Mo-tan;CUI Gang;WEI Wan-chun;KE Ying-shui(Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China;China-Japan Friendship Hospital,Beijing 100029,China;Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2020年第11期5835-5837,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
中国中医科学院望京医院院级科研课题(No.WJYY2016-PY-040)。
关键词
氨基酸
肉碱
艾灸
血液透析
蛋白质能量消耗
Amino acids
Carnitine
Moxibustion
Hemodialysis
Protein energy wasting
