摘要
Summary of main observation and conclusion Selenium and copper synergistically catalyzed the oxidation/alkoxylation of methyl ketones to synthesize a-keto acetals directly.Using 02 as oxidant and alcohol as solvent and alkoxylation reagent,the reaction is practical from industrial viewpoint.Mechanistic studies revealed that copper promoted the oxidation of organoselenium intermediates with O2 to allow the key rearrangement and selenoxide syn-elim-ination regenerating the catalytically active organoselenium species.
基金
We thank the Natural Science Foundation of Jiangsu Province(BK20181449)
the Jiangsu Provincial Six Talent Peaks Project(XCL-090),the National Natural Science Foundation of China(Nos.21202141,21971065)
the Priority Academic Program Devel-opment(PAPD)of Jiangsu Higher Education Institutions.
