摘要
目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因多态性与血清叶酸、同型半胱氨酸代谢的关系。方法随机收集2019年1—12月在该院同时检测外周血细胞MTHFR基因检测、血清叶酸、血清同型半胱氨酸检测的500例受试者资料,进行统计学分析。结果500例受试者中MTHFR基因为CC型(正常野生型)220例(44.0%)、CT型(杂合突变型)145例(29.0%)、TT型(纯合突变型)135例(27.0%)。不同性别及年龄段受试者的各基因型分布比例比较,差异无统计学意义(P>0.05)。TT型和CT型受试者血清叶酸水平低于正常参考范围的人数明显多于CC型受试者,差异有统计学意义(P<0.05);TT型和CT型受试者血清同型半胱氨酸高于正常参考范围的人数明显多于CC型受试者,差异有统计学意义(P<0.05)。结论MTHFR TT型和CT型两类人群应定期监测血清叶酸和同型半胱氨酸水平,减少因叶酸和同型半胱氨酸代谢障碍而引发相关疾病的风险。
Objective To investigate the relationship between methylene tetrahydrofolate reductase(MTHFR)gene polymorphism and serum folic acid and homocysteine metabolism.Methods The data of 500 subjects who were tested for MTHFR gene,folic acid and homocysteine in peripheral blood in the hospital from January to December 2019 were randomly collected for statistical analysis.Results Among the 500 subjects,220(44.0%)of The MTHFR gene were CC type(normal wild type),145(29.0%)of CT type(heterozygous mutant)and 135(27.0%)of TT type(homozygous mutant).There was no statistically significant difference(P>0.05)in the distribution ratio of genotypes among different genders and age groups.The number of serum folic acid levels of TT type and CT type were lower than the normal reference range was significantly higher than that of CC type(P<0.05).The number of serum homocysteine levels higher than the normal reference range in TT and CT was significantly higher than that in CC,with statistically significant difference(P<0.05).Conclusion Serum folic acid and homocysteine levels should be regularly monitored in TT and CT MTHFR genotypes to reduce the risk of related diseases caused by folic acid and homocysteine metabolic disorders.
作者
陈爱保
向欢
赵红萍
CHEN Aibao;XIANG Huan;ZHAO Hongping(Department of Clinical Laboratory,Shenzhen Heng Sheng Hospital,Shenzhen,Guangdong 518102,China)
出处
《检验医学与临床》
CAS
2020年第23期3453-3454,3458,共3页
Laboratory Medicine and Clinic
