摘要
目的分析初诊多发性骨髓瘤患者的血钙水平,以及校正后血钙与临床特征的相关性。方法回顾性分析西安交通大学第一附属医院2015年7月至2017年6月收治的205例初诊多发性骨髓瘤患者的临床资料,当患者的清蛋白水平低于40 g/L时,即对其血钙水平进行校正。分析校正血钙与年龄、全血细胞计数、血清清蛋白、尿素氮、肌酐、尿酸、β2微球蛋白、胱抑素C、血磷、乳酸脱氢酶、碱性磷酸酶、骨髓瘤细胞百分比及骨损伤分级等的相关性。结果校正后正常钙组和高水平钙组患者比例升高,低水平钙组比例降低;临床分期越高,高血钙的发生率越高;校正后血钙水平与血清清蛋白、尿素氮、肌酐、尿酸、β2微球蛋白、胱抑素C和骨髓瘤细胞百分比显著相关,与年龄、血红蛋白、淋巴细胞绝对值、红细胞比容、血磷、乳酸脱氢酶及碱性磷酸酶无关;低水平钙组、正常钙组肾功能受损例数与高水平钙组比较,差异有统计学意义(P<0.05);正常钙组骨质受损例数与高水平钙组比较,差异有统计学意义(P<0.05)。结论根据血清清蛋白对血钙水平进行校正是必要的,校正后血钙可有效反映疾病的严重程度。
Objective To analyze the serum calcium levels in newly diagnosed multiple myeloma patients and the correlation between corrected serum calcium levels and clinical characteristics.Methods The clinical data of 205 newly diagnosed multiple myeloma patients admitted to the First Affiliated Hospital of Xi'an Jiaotong University from July 2015 to June 2017 were retrospectively analyzed.When the albumin level of the patients was lower than 40 g/L,the serum calcium level needed to be corrected.Analysis the correlation between the corrected serum calcium and age,full blood count,serum albumin,urea nitrogen,creatinine,uric acid,β2-microglobulin,cystatin C,serum phosphorus,lactate dehydrogenase,alkaline phosphatase,percentage of myeloma cells,bone injury grade,etc.Results After correction,the proportion of patients in the normal calcium group and the high level calcium group increased,while that in the low level calcium group decreased.The higher the clinical stage,the higher the incidence of hypercalcemia.The corrected serum calcium levels were significantly correlated with serum albumin,urea nitrogen,creatinine,uric acid,β2-microglobulin,cystatin C and percentage of myeloma cells,but not correlated with age,hemoglobin,absolute lymphocyte values,hematocrit,serum phosphorus,lactate dehydrogenase,and alkaline phosphatase.The number of renal damage cases in the low level calcium group and the normal calcium group was statistically significant compared with the high level calcium group(P<0.05).The number of cases of bone damage in the normal calcium group was statistically significant compared with that in the high calcium group(P<0.05).Conclusion It is necessary to correct serum calcium level according to serum albumin,which can effectively reflect the severity of the disease.
作者
吉莉
郭炫
JI Li;GUO Xuan(Department of Clinical Laboratory,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi 710061,China;Department of Clinical Laboratory,Baoji Central Hospital,Baoji,Shaanxi 721008,China)
出处
《检验医学与临床》
CAS
2020年第23期3429-3431,共3页
Laboratory Medicine and Clinic
基金
陕西省国际科技合作交流计划项目(2016KW-007)。
关键词
多发性骨髓瘤
校正血钙
骨髓瘤骨病
multiple myeloma
corrected blood calcium
myeloma bone disease
