摘要
高血糖是导致认知功能障碍的独立危险因素,可加速轻度认知功能障碍向痴呆的转化。糖尿病是21世纪全球范围内最严重的公共卫生问题之一,随着其患病人数的增加,2型糖尿病(T2DM)相关认知功能障碍得到更多的重视。T2DM相关认知功能障碍主要表现在记忆力、注意力、信息处理速度和执行功能等方面,T2DM患者脑磁共振成像的研究表明T2DM患者与无糖尿病患者相比:脑体积减小,腔隙性脑梗死发生率增加,脑白质纤维束完整性下降,脑区激活功能降低,各脑区间功能和结构连接下降,脑代谢物质水平改变。
Hyperglycemia is an independent risk factor for cognitive dysfunction and may accelerate the progression of mild cognitive impairment to dementia.Diabetes mellitus is one of the most serious public health problems in the 21st century around the world.With the number of diabetic patients increased,more attention has been paid to type 2 diabetes mellitus related cognitive dysfunction.The type 2 diabetes mellitus related cognitive dysfunction mainly displays in the memory,attention,information processing speed and executive functions,etc..Magnetic resonance imaging(MRI)studies have shown that,compared with patients without diabetes,type 2 diabetes mellitus patients can be present more often with the reduction of the brain volume,the incidence of lacunar cerebral infarction,the loss of cerebral white matter fiber tracts integrity,and the diminishment of brain activation function,the decline of brain function of interval nuclear structure connection,and the change of the cerebral metabolic material level.
作者
李梦春
赵辉
徐运
Li Mengchun;Zhao Hui;Xu Yun(Department of Neurology,Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China)
出处
《中华脑血管病杂志（电子版）》
2020年第5期292-296,共5页
Chinese Journal of Cerebrovascular Diseases(Electronic Edition)
基金
国家自然科学基金(81920108017,81630028,81771157)
江苏省科技厅医学重点项目(BE2016610)
江苏省医学重点学科(ZDXKA2016020)。
关键词
2型糖尿病
认知功能障碍
磁共振成像
Type 2 diabetes mellitus
Cognitive impairment
Magnetic resonance imaging
