摘要
慢性肾脏病现已成为全球性公共健康问题,在慢性肾脏病(chronic kidney disease,CKD)患者中,几乎都存在不同程度的钙磷代谢紊乱、甲状旁腺功能亢进、心血管病变、贫血、炎症等并发症,严重影响CKD的进展和预后。成纤维细胞生长因子23(FGF23)是一种调节磷酸盐和维生素D代谢的骨源性激素。既往认为FGF23只是在钙磷代谢相关调解中发挥重要作用,近年来发现FGF23与多种CKD并发症的发生或进展有关,为研究FGF23在慢性肾脏病病程中的作用开拓了新的视野,FGF23有望成为新的治疗靶点,改善CKD患者预后。本文将围绕FGF23的生物学特性及其在CKD疾病进展中所发挥的作用进行综述,并简要讨论其在慢性肾脏疾病中潜在的未来作用。
Chronic kidney disease is now a global public health problem.In chronic kidney disease(CKD)patients,almost all have complications such as calcium and phosphorus metabolism disorders,hyperparathyroidism,cardiovascular disease,anemia,and inflammation,which seriously affect the progress and prognosis of CKD.Fibroblast growth factor 23(FGF23)is a bone-derived hormone that regulates the metabolism of phosphate and vitamin D.In the past,FGF23 was generally considered to play only an important role in the regulation of calcium and phosphorus metabolism.In recent years,FGF23 has been found to be associated with the occurrence or progression of various CKD complications.This opens up new horizons for studying the role of FGF23 in the course of chronic kidney disease.FGF23 is expected to become a new therapeutic target in the future,improving the prognosis of patients with CKD.This article will review the biological characteristics of FGF23 and its role in the progression of CKD.And briefly discuss its potential future role in chronic kidney disease.
作者
廖柄清
刘欣武
赵成波
王润秀
LIAO Bing-qing;LIU Xin-wu;ZHAO Cheng-bo;WANG Run-xiu(Postgraduate students of Gannan Medical University,Grade 2018;Department of Nephrology,The First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000)
出处
《赣南医学院学报》
2020年第10期1080-1086,共7页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
成纤维细胞生长因子
肾功能不全
肾脏病学
磷代谢障碍
心血管疾病
Fibroblast growth factors
Renal insufficiency
Nephrology
Phosphorus metabolism disorders
Cardiovascular diseases
