摘要
目的:探讨胸腺肽α1联合纤维支气管镜肺灌洗治疗重症肺炎合并脓毒症的临床效果。方法:将2017年2月-2019年10月笔者所在医院治疗的58例重症肺炎合并脓毒症的患者随机分为观察组和对照组,每组29例。对照组在常规治疗的基础上采用纤维支气管镜直视下对患者进行肺泡灌洗。每周灌洗治疗1~2次,2周为1个疗程。观察组在对照组的基础上皮下注射胸腺肽α1治疗,连续用药10 d为1个疗程,灌洗1个疗程。评估和比较两组患者治疗前后生命体征、血气分析、炎症指标情况。结果:两组治疗后的生命体征(呼吸频率、心率、体温)、白细胞计数、血气分析和炎症指标均优于治疗前(P<0.05);观察组治疗后患者呼吸频率、心率、白细胞计数改善情况显著优于对照组,pH、PaCO2、PaO2/FiO2优于对照组(P<0.05);观察组治疗后血清CRP、PCT、TNF-α、IL-6水平明显低于对照组,临床有效率优于对照组(P<0.05)。结论:胸腺肽α1联合纤维支气管镜肺灌洗可以改善重症肺炎合并脓毒症患者临床症状,抑制炎症进展,提高临床疗效。
Objective:To explore the clinical efficacy of Thymosin α1 combined with bronchoscopy lung lavage in the treatment of severe pneumonia with sepsis.Method:A total of 58 patients with severe pneumonia and sepsis treated in our hospital from December 2018 to January 2020 were randomly divided into an observation group and a control group,with 29 cases in each group.In the control group,patients underwent alveolar lavage under direct treatment with fiberoptic bronchoscopy on the basis of conventional treatment.Irrigation treatment 1 time to 2 times a week,two weeks of treatment.In the observation group,Thymosinα1 was injected subcutaneously on the basis of the control group,one per time,once a day,for a treatment course of 10 days.The vital signs,blood gas analysis and inflammation indexes of the two groups of patients before and after treatment were evaluated.Result:The vital signs(breathing rate,heart rate,body temperature),white blood cell count,blood gas analysis,and inflammation indexes of the two groups after treatment were better than those before treatment(P<0.05).Compared with the two groups after treatment,it was found that the observation group’s breathing and heart rate,body temperature,and white blood cell count were significantly better than those in the control group,and the pH,PaCO2,and PaO2/FiO2 after treatment of the observation group were significantly better than those of the control group(P<0.05).In addition,the serum CRP,PCT,TNF-α,IL-6 levels of the observation group after treatment were significantly lower than the control group,and the clinical effective rate was better than the control group(P<0.05).Conclusion:Thymosinα1 combined with bronchofiberoscope lung lavage can improve the clinical symptoms of patients with severe pneumonia and sepsis,inhibit the progress of inflammation,and improve the clinical efficacy.
作者
刘志敏
关远志
陈时松
LIU Zhimin;GUAN Yuanzhi;CHEN Shisong(Yangchun City People’s Hospital,Yangchun 529600,China;不详)
出处
《中外医学研究》
2020年第31期8-11,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
阳江市科技计划项目(社发【2019】128)。
