摘要
目的探讨MR泪道钆造影(Gd-MRD)技术,并比较Gd-MRD与MR泪道水成像(MRD)对泪道及其管壁结构的显示效果。方法(1)体外实验:取4支20 ml注射器,分别注入钆喷酸葡胺注射液(Gd-DTPA)与0.9%NaCl注射液配制的浓度分别为0.0025 mol/L、0.005 mol/L、0.01 mol/L、0.02 mol/L的Gd-DTPA稀释液。选用三维快速扰相梯度回波(3D FSPGR)序列、FS FSE T1WI序列和FS FSE T2WI序列。选择出最佳的浓度。(2)临床应用:30例(60侧)健康志愿者同时行MRD和Gd-MRD检查,MRD方法为检查前向双侧结膜囊滴入0.9%NaCl注射液,扫描序列为三维快速反转自旋回波(3D-FRFSE)序列和FS FSE T2WI序列;Gd-MRD方法为检查前向双侧结膜囊内滴入0.01 mol/L的Gd-DTPA稀释液,采用3D FSPGR序列、FS FSE T1WI序列和FS FSE T2WI序列。由两位放射科医师双盲法观察MRD和Gd-MRD的泪道(泪小管及泪总管、泪囊、鼻泪管)及其管壁结构显示情况,并对结果进行统计学分析。结果(1)对比剂浓度:0.01 mol/L的Gd-DTPA稀释液在3D-FSPGR及T1WI序列呈高信号,又能在T2WI序列上呈低信号,为最佳的浓度。(2)临床应用:MRD泪道显示情况:泪小管及泪总管显示9侧(全程显影1侧,部分显影8侧),泪囊显示60侧(全程显影49侧,部分显影11侧),鼻泪管显示57侧(全程显影46侧,部分显影11侧),鼻泪管黏膜显示18侧;Gd-MRD泪道显示情况:泪小管及泪总管显示34侧(全程显影20侧,部分显影14侧),泪囊显示60侧(全程显影57侧,部分显影3侧),鼻泪管显示60侧(全程显影53侧,部分显影7侧),鼻泪管黏膜显示45侧。Gd-MRD与MRD在泪道各段的显示和鼻泪管黏膜的显示均有显著差异(P<0.05)。结论浓度为0.01 mol/L的Gd-DTPA稀释液作为Gd-MRD对比剂时,Gd-MRD泪道各段显示能力均优于MRD,能更好的显示泪道管腔形态及管壁结构。MR泪道钆造影术是一种简便、安全、无创的泪道MRI检查新方法。
Objective To explore the technique of gadolinium MR dacryocystography(Gd-MRD),and to compare the imaging characteristics of Gd-MRD and MR dacryocystography(MRD)on the lacrimal duct and its wall structure.Methods(1)In vitro experiment:Take 420 ml syringes and inject Gd-DTPA injection(Gd-DTPA)and 0.9%NaCl injection with the concentration of 0.0025 mol/L,0.005 mol/L,0.01 mol/L,0.02 mol/L Gd-DTPA diluent.Choose three-dimensional fast spoiled gradient echo(3 D FSPGR)sequence,FS FSE T1 WI sequence and FS FSE T2 WI sequence.Chose the best concentration.(2)Clinical application:30 healthy volunteers(60 sides)underwent MRD and Gd-MRD examinations at the same time.The MRD method was to instill 0.9%Na Cl injection into the bilateral conjunctival sac before the examination.Three-dimension fast relaxation fast spin echo(3 D-FRFSE)sequence and FS FSE T2 WI sequence;Gd-MRD method is to instill 0.01 mol/L Gd-DTPA diluent into the bilateral conjunctival sac before inspection,using 3 D FSPGR sequence,FS FSE T1 WI sequence and FS FSE T2 WI sequence.Two radiologists double-blindly observed the display of the lacrimal duct(lacrimal duct and common lacrimal duct,lacrimal sac,nasolacrimal duct)and its tube wall structure of MRD and Gd-MRD,and statistically analyzed the results.Results(1)Contrast agent concentration:0.01 mol/L Gd-DTPA diluent showed high signal on 3 D-FSPGR and T1 WI sequence,and low signal on T2 WI sequence,which was the best concentration.(2)Clinical application:MRD lacrimal duct display,9 sides of lacrimal canaliculus and common lacrimal duct(1 side in full visualization,8 sides in partial visualization),60 sides in lacrimal sac display(49 sides in full visualization,11 sides in partial visualization),nose Lacrimal ducts show 57 sides(46 sides for full imaging,11 sides for partial imaging),nasolacrimal duct mucosa shows 18 sides;Gd-MRD lacrimal duct shows,canaliculus and common lacrimal duct show 34 sides(20 sides for full imaging,14 sides for partial imaging)Side),the lacrimal sac shows 60 sides(57 sides for full vis
作者
丁凯俊
史斌
江时淦
沈龙
彭建波
饶丽望
刘越
江宏冀
陈娟娟
DING Kaijun;SHI Bin;JIANG Shigan(Department of Radiology,First Affiliated Hospital of Jiangxi Medical College,Shangrao,Jiangxi Province 334000,P.R.China)
出处
《临床放射学杂志》
CSCD
北大核心
2020年第7期1277-1281,共5页
Journal of Clinical Radiology
基金
江西省卫生计生委科技计划项目(编号:20197550)。
关键词
泪道
磁共振成像
钆剂
泪囊造影术
Lacrimal passage
Magnetic resonance imaging
Gadolinium
Dacryocystography
