摘要
目的分析阿奇霉素联合热毒宁注射液对急性支气管肺炎患儿的治疗效果及其肺功能的影响。方法将锦州市妇婴医院2017年1月~2019年12月收治的118例急性支气管肺炎患儿作为研究对象,按照随机数字表法均分为对照组(59例)和观察组(59例)。对照组给予阿奇霉素常规治疗,观察组给予阿奇霉素联合热毒宁注射液治疗。分析两组临床表现,比较两组疗效、肺功能指标和炎症因子,观察不良反应的发生情况。结果治疗后两组的发热、咳嗽和(或)咳痰、肺部体征、血象异常等临床表现评分低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。两组治疗后潮气量(TV)、达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)和吸呼比(TI/TE)均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后两组白细胞介素-6、肿瘤坏死因子-α和超敏C反应蛋白水平低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。两组不良反应情况比较,差异无统计学意义(P>0.05)。结论阿奇霉素联合热毒宁注射液可以缓解急性支气管肺炎患儿的临床表现,改善肺功能,疗效显著,安全性高。
Objective To analyze the effect of Azithromycin combined with Reduning Injection on children with acute bronchopneumonia and its pulmonary function.Methods A total of 118 children with acute bronchial pneumonia admitted to Women and Children′s Hospital of Jinzhou from January 2017 to December 2019 were taken as research objects,and they were divided into the control group(59 cases)and the observation group(59 cases)according to the random number table method.The patients of control group were treated with Azithromycin,the patients of observation group were treated with Azithromycin and Reduning Injection.The clinical manifestations of the two groups were analyzed,the curative effect,pulmonary function indexes and inflammatory factor were compared,and the occurrence of adverse reactions were observed.Results After treatment,the scores of clinical manifestations such as fever,cough and/or sputum,lung signs,and abnormal blood picture in the two groups were lower than those before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).After treatment,the tidal volume(TV),peak time ratio(TPTEF/TE),peak volume ratio(VPEF/VE)and inspiratory-expiratory ratio(TI/TE)pulmonary function indexes were higher than those before treatment in the two groups,and those in the group were higher than those of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6,tumor necrosis factor-αand hypersensitive C-reactive protein in the two groups were lower than those before treatment,and those in the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion Azithromycin combined with Reduning I
作者
王琦
李迎春
何平
WANG Qi;LI Ying-chun;HE Ping(Department of Pediatrics,Women and Children′s Hospital of Jinzhou,Liaoning Province,Jinzhou121001,China)
出处
《中国当代医药》
2020年第32期127-130,共4页
China Modern Medicine
关键词
热毒宁注射液
急性支气管肺炎
阿奇霉素
肺功能
临床表现
炎症因子
Reduning Injection
Acute bronchitis pneumonia
Pulmonary function
Clinical manifestation
Inflammatory factor
