摘要
To the Editor:Wake-up stroke(WUS)is the name given to an ischemic stroke that occurs primarily during night-time sleep and accounts for approximately 20%of all cases of acute ischemic stroke(AIS).Epidemiological studies have demonstrated a circadian distribution of AIS,with a higher frequency in the morning and a lower frequency during sleep.[1]It remains unclear whether WUS is a stochastic event or if a distinct pathophysiologic process,such as circadian rhythm disorder,differentiates WUS from daytime stroke(non-WUS).
基金
grants from the National Key Research&Development Program of China(No.2017YEE0103700)
the Social Development Project of Jiangsu(No.BE2016670)。
