摘要
目的探讨煤矿接矽尘工人血清中总抗氧化能力(total antioxidant capacity,TAC)、转化生长因子-β1(transforming growth factor-β1, TGF-β1)表达水平与矽肺的相关性。方法采用限制性三次样条(restricted cubic spline,RCS)结合Logistics回归,分析随机选取的137例煤矿工人(接尘组)和94例壹期矽肺患者(病例组)血清中TAC与TGF-β1的剂量-效应关系及其对矽肺发病的影响。结果 TAC、TGF-β1、年龄及吸烟在接尘组和病例组之间差异有统计学意义(P<0.05);接尘组血清TAC水平工龄11~20年组高于1~10年组,差异有统计学意义(P<0.05);病例组血清TGF-β1水平工龄11~20年组低于1~10年、21~38年组,差异均有统计学意义(P<0.05)。RCS模型分析结果显示,接尘组和病例组TAC、TGF-β1水平间均存在相关性,且在接尘组中两者呈非线性关系(总体关联性检验χ2=8.010,P=0.046和χ2=7.870,P=0.049;非线性检验χ2=6.580,P=0.037和χ2=3.340,P=0.188)。多因素分析显示,调整潜在混杂因素后(年龄、文化程度、接尘工龄、开始接尘年龄和吸烟),TGF-β1与矽肺发病风险升高有关(OR=1.022,95%CI 1.006~1.039),TAC与矽肺发病风险降低有关(OR=0.897,95%CI 0.847~0.951)。结论煤矿接尘工人及矽肺患者血清TAC、TGF-β1含量与矽肺相关。
Objective To investigate the correlation between serum total antioxidant capacity(TAC),transforming growth factor-β1(TGF-β1)and silicosis in coal mine workers exposed to silica dust.Methods A total of 137 coal mine workers and 94 patients with stage Ⅰ silicosis were randomly selected as the study subjects,and the restricted cubic spline(RCS)and Logistic regression methods were used for the analysis of the dose-response relationship between silicosis and serum TAC or TGF-β1.Results The results showed that there were statistically significant differences in TAC and TGF-β1 content in serum,age,and smoking between dust exposed group and silicosis group(P<0.05);the serum TAC levels in 11~20 years subgroup was higher than that in 1~10 years subgroup in dust exposed group,the difference was statistically significant(P<0.05), while the serum TGF-β1 content in 11~20 years subgroup was lower than that in 1~10 years subgroup and 21~38 years subgroup in silicosis group,the difference was statistically significant(P<0.05).furthermore, the results of RCS showed that there was some correlation between TAC and TGF-β1 content both in dust exposure group and silicosis group,but the correlation in dust exposure group was non-linear(the overall correlation test:χ~2=8.010,P=0.046 and χ~2=7.870,P=0.049;the non-linear test:χ~2=6.580,P=0.037 and χ~2=3.340,P=0.188).The multivariate analysis showed that serum level of TGF-β1 was associated with the increased risk of silicosis(OR=1.022,95%CI 1.006~1.039)and TAC was associated with the decreased risk of silicosis(OR=0.897,95%CI 0.847~0.951)after adjusting for potential confounding factors including age,education level,duration of dust exposure,age of dust exposure,smoking,etc.Conclusions The results suggested that there was some correlation between serum TAC,TGF-β1 content and silicosis in the coal mine workers exposed to silica dust.
作者
赵英政
常美玉
熊程
关毅
司学哲
李志恒
李国锋
李海斌
李玉春
徐光翠
王永斌
姚三巧
ZHAO Ying-zheng;CHANG Mei-yu;XIONG Cheng;GUAN Yi;SI Xue-zhe;LI Zhi-heng;LI Guo-feng;LI Hai-bin;LI Yu-chun;XU Guang-cui;Wang Yong-bin;YAO San-qiao(College of Public Health,North China University of Science and Technology,Tangshan 063000,China)
出处
《中国工业医学杂志》
CAS
2020年第5期403-406,456,共5页
Chinese Journal of Industrial Medicine
基金
国家自然科学基金项目(81773399)
中国煤炭工业协会2018年指导性计划项目(MTKJ-2018284)
华北理工大学研究生创新项目(2017B12)。
