摘要
收集梁德教授采用中药治疗腰腿痛患者有效病例的门诊处方,基于中医传承辅助平台(V2.5),采用该软件集成的关联规则分析、改进互信息法、复杂系统熵聚类及无监督的熵层次聚类等数据挖掘方法,对梁德教授门诊治疗腰腿痛的中药处方用药规律进行分析。结果显示,纳入的324首处方中,共涉及中药113味,使用频次居前5位的分别为牛膝、炙甘草、续断、独活、杜仲;药物的四气五味等频次分析结果显示,所用药物药性偏温,以苦、甘、辛味药为主,归经主要归于肝、肾、脾经,证候分型以肝肾亏虚、湿热、气滞血瘀为主;演化得到4首新方组合,分别为新方1:柴胡、白芍、三棱、苍术、蚕砂;新方2:柴胡、白芍、丹参、淫羊藿;新方3:川芎、苍术、生地黄、熟地黄;新方4:苍术、薏苡仁、生地黄、党参。分析结果提示,梁德教授治疗腰腿痛用药以补益肝肾、清热祛湿为主,其次采用温经散寒,辅以补气滋阴、祛风止痛。
In this study,we collected the information of the prescriptions for the effective cases of lumbago and scelalgia outpatients treated by professor LIANG De,and then adopted the data mining ways of association rule analysis,improved mutual information method,complex system entropy-based clustering,and unsupervised entropy-based hierarchical clustering supplied by the Traditional Chinese Medicine Inheritance Support System(V2.5)to mine the principles for the prescription and medication during the treatment of lumbago and scelalgia by Professor LIANG De in clinic.The results showed that a total of 324 recipes were included,involving 113 herbs.The herbs with the leading 5 medication frequency were Radix Achyranthis Bidentatae,Radix Glycirrhizae Preparata,Radix Dipsaci,Radix Angelicae Pubescentis,and Cortex Eucommiae.The results of the frequency analysis for the four properties and five tastes of the herbs showed that the medicated herbs were predominated by the warm nature and the bitter,sweet,and pungent flavors,and mainly had the meridian tropism of liver,kidney and spleen meridians.The lumbago and scelalgia were mainly differentiated into the liver and kidney insufficiency syndrome,damp-heat syndrome,and qi stagnation and blood stasis syndrome.Four new candidate recipes were derived from the clustering results,and they were the recipe 1(mainly composed of Radix Bupleuri,Radix Paeoniae Alba,Rhizoma Sparganii,Rhizoma Atractylodis,and Feculae Bombycis),the recipe 2(mainly composed of Radix Bupleuri,Radix Paeoniae Alba,Radix Salviae Miltiorrhizae,and Herba Epimedii),the recipe 3(mainly composed of Rhizoma Chuanxiong,Rhizoma Atractylodis,Radix Rehmanniae,and Radix Rehmanniae Preparata),and the recipe 4(mainly composed of Rhizoma Atractylodis,Semen Coicis,Radix Rehmanniae,and Radix Codonopsis).The results indicated that professor LIANG De frequently adopts the therapies of tonifying liver and kidney,clearing heat and removing dampness,usually uses the therapy of warming meridians and dispersing cold,and uses the therapie
作者
余翔
任辉
沈耿杨
方志超
唐晶晶
林少豪
吴智华
张嘉锐
张志达
江晓兵
梁德(指导)
YU Xiang;REN Hui;SHEN Geng-Yang;FANG Zhi-Chao;TANG Jing-Jing;LIN Shao-Hao;WU Zhi-Hua;ZHANG Jia-Rui;ZHANG Zhi-Da;JIANG Xiao-Bing;LIANG De(Dept.of Spinal Surgery,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;The First Clinical Medical School,Guangzhou University of Chinese medicine,Guangzhou 510405 Guangdong,China;Lingnan Medical Research Center of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2020年第12期2435-2440,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
国家自然科学基金项目(编号:81674000,81774338)
广东省高等学校珠江学者岗位计划资助项目(编号:GDUPS 2018)
广州中医药大学第一附属医院“创新强院”工程科研项目(编号:2017TD08)
广州中医药大学第一临床医学院优秀博士学位论文培育项目(编号:YB201702)
2018年广州中医药大学优秀博士论文培育项目(编号:A1-2606-19-429-012)。
关键词
腰腿痛
补益肝肾
清热祛湿
牛膝
续断
独活
杜仲
数据挖掘
用药规律
梁德
lumbago and scelalgia
tonifying liver and kidney
clearing heat and removing dampness
Radix Achyranthis Bidentatae
Radix Dipsaci
Radix Angelicae Pubescentis
Cortex Eucommiae
data mining
medication principles
LIANG De