摘要
【目的】观察温针灸命门穴治疗寒湿痹阻型难治性痛风性关节炎的临床疗效。【方法】将110例寒湿痹阻型难治性痛风性关节炎患者随机分为治疗组和对照组,每组各55例。对照组给予常规西药(西乐葆和碳酸氢钠)口服治疗,治疗组在对照组基础上加用温针灸命门穴治疗,疗程为14 d。观察2组患者治疗前后疼痛视觉模拟量表(VAS)评分、中医证候积分和相关实验室指标[血尿酸(BUA)、超敏C反应蛋白(hs-CRP)、血沉(ESR)]的变化情况,评价2组患者的中医证候疗效和安全性。【结果】(1)治疗14 d后,治疗组的总有效率为98.2%(54/55),对照组为81.8%(45/55),治疗组的中医证候疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的VAS评分和中医证候积分均较治疗前明显降低(P<0.05),且治疗组的降低作用均明显优于对照组,差异均有统计学意义(P<0.05)。(3)治疗后,2组患者的BUA、hs-CRP和ESR水平均较治疗前明显降低(P<0.05),且治疗组的降低作用均明显优于对照组,差异均有统计学意义(P<0.05)。(4)治疗过程中,2组患者均无明显不良反应,且患者的血尿常规、肝肾功能和心电图等均无明显异常变化。【结论】在常规西药治疗的基础上配合温针灸命门穴治疗寒湿痹阻型难治性痛风性关节炎疗效肯定,不仅能有效改善中医证候,缓解关节疼痛,而且在降低患者的血尿酸和相关炎症指标方面更有优势,同时具有较高的安全性。
Objective To observe the therapeutic effect of warm-needling moxibustion at Mingmen point(GV4)for the treatment of refractory gouty arthritis patients with cold-damp obstruction syndrome.Methods A total of 110 intractable gouty arthritis patients with cold-damp obstruction syndrome were randomly divided into treatment group and control group,with 55 cases in each group.The control group was given oral administration of Celox Tablets and Sodium Bicarbonate Tablets,and the treatment group was given warm-needling moxibustion at Mingmen point(GV4)based on the treatment for the control group.The treatment for the two groups lasted for 14 days.Before and after treatment,the pain scores evaluated with visual analogue scale(VAS),scores of traditional Chinese medicine(TCM)syndrome,and the levels of associated laboratory indicators of blood uric acid(BUA),high-sensitivity C-reactive protein(hs-CRP),and erythrocyte sedimentation rate(ESR)in the two groups were observed.The clinical efficacy for TCM syndrome and the clinical safety in the two groups after treatment were also evaluated.Results(1)After 14 days of treatment,the total effective rate of the treatment group was 98.2%(54/55)and that of the control group was 81.8%(45/55).The intergroup comparison showed that the treatment group had stronger efficacy for TCM syndrome than the control group,and the difference was statistically significant(P<0.05).(2)After treatment,VAS scores and the scores of TCM syndrome in the two groups were obviously decreased in comparison with those before treatment(P<0.05),and the decrease in the treatment group was superior to that in the control group,the difference being statistically significant(P<0.05).(3)After treatment,the serum levels of BUA,hs-CRP and ESR in the two groups were obviously decreased in comparison with those before treatment(P<0.05),and the decrease in the treatment group was superior to that in the control group,the difference being statistically significant(P<0.05).(4)During the trial,no obvious adverse reaction was fo
作者
陈子晴
聂斌
CHEN Zi-Qing;NIE Bin(The Fifth Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510095 Guangdong,China;Dept.of Acupuncture and Moxibustion,the Second Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510095 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2020年第12期2365-2369,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
温针灸
命门穴
寒湿痹阻
难治性痛风性关节炎
warm-needling moxibustion
Mingmen point(GV4)
cold-damp obstruction
refractory gouty arthritis
