摘要
目的探讨基础胰岛素联合短效胰岛素与预混胰岛素治疗对2型糖尿病患者体质量指数(BMI)、甘油三酯(TG)、胰岛素剂量的影响对比。方法选取2017年3月至2020年3月收治的2型糖尿病患者240例,随机分为研究组和对照组各120例,对照组给予预混胰岛素治疗,研究组给予基础胰岛素联合短效胰岛素治疗。观察分析2组患者血糖、血脂指标变化情况、临床疗效、胰岛素使用剂量以及低血糖发生情况等。结果研究组TG以及高密度脂蛋白(HDL)等血脂指标改善水平明显优于对照组(P<0.05);研究组临床疗效明显高于对照组(P<0.05);研究组空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbAlc)以及身体质量指数(BMI)等指标改善水平明显优于对照组(P<0.05);研究组胰岛素使用剂量以及低血糖发生率明显低于对照组(P<0.05),且患者满意度明显高于对照组(P<0.05)。结论2型糖尿病患者应用基础胰岛素联合短效胰岛素治疗效果理想,可有效促进低血糖等不良症状改善,使患者血糖以及血脂水平尽快恢复到正常范围,还能进一步减少胰岛素药物的使用剂量,减轻对患者身体的损伤,可推广使用。
Objective To explore the effects of basal insulin combined with short-acting insulin and premixed insulin on BMI,TG,and insulin dose in patients with type 2 diabetes.Methods A total of 240 patients with type 2 diabetes who were treated from March 2017 to March 2020 were randomly divided into a study group and a control group,120 cases in each group.The control group was given pre-mixed insulin treatment,and the study group was given basic insulin combined with short-acting insulin.treatment.We observed and analyzed the changes in blood glucose,blood lipid index,clinical efficacy,dosage of insulin and occurrence of hypoglycemia in the two groups of patients.Results The improvement levels of blood lipid indexes such as triglyceride(TG)and high-density lipoprotein(HDL)in the study group were significantly better than those in the control group(P<0.05);the clinical efficacy of the study group was significantly higher than that of the control group(P<0.05);The improvement levels of fasting blood glucose(FPG),two-hour blood glucose(2 hPG),glycated hemoglobin(HbA1c),and body mass index(BMI)in the group were significantly better than those in the control group(P<0.05).The incidence of blood glucose was significantly lower than that of the control group(P<0.05),and patients satisfaction was significantly higher than that of the control group(P<0.05).Conclusion The application of basal insulin combined with short-acting insulin in patients with type 2 diabetes has an ideal effect,which can effectively promote the improvement of adverse symptoms such as hypoglycemia,restore the patient′s blood glucose and blood lipid levels to the normal range as soon as possible,and further reduce the dosage of insulin dosage and reduce damage to the patient′s body.It can be promoted.
作者
刘泮力
王尚农
段玉敏
施康平
肖英丽
朱瑾英
Liu Panli;Wang Shangnong;DuanYumin;Shi Kangping;Xiao Yingli;Zhu Jinying(Department of Endocrinology,Beijing Sixth Hospital,Beijing 100007,China)
出处
《山西医药杂志》
CAS
2020年第22期3058-3061,共4页
Shanxi Medical Journal
