摘要
新型冠状病毒(SARS-CoV-2)具有高度传染性,感染者有较高死亡风险.血管紧张素转换酶2(ACE2)是SARS-CoV-2受体,其组织器官分布和表达丰度与病毒易感性关系密切,病毒感染者易发生呼吸、循环、泌尿和消化等系统疾病.但ACE2高表达并不意味疾病预后严重,研究表明,ACE2通过调节肾素-血管紧张素系统(renin angiotensin system,RAS)影响疾病进程.
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a highly contagious from person to person,and the infected people have a higher risk of respiratory failure.Angiotensin-converting enzyme 2(ACE2)is the receptor of SARS-CoV-2.As a result,the distribution and expression of ACE2 may be crucial to SARS-CoV-2 infection to target organs.Patients with viral infection are prone to respiratory,circulatory,urinary and digestive diseases.High expression of ACE2 does not mean a serious prognosis of the disease,the study shows that ACE2 affects disease progression by regulating ACE2.
作者
阮颖新
张鹏宇
Ruan Ying-xin;Zhang Peng-yu(Department of Nephrology,General Hospital of Tianjin Medical University,Tianjin 300052,China)
出处
《中国急救医学》
CAS
CSCD
北大核心
2020年第10期1003-1007,共5页
Chinese Journal of Critical Care Medicine
基金
国家自然科学基金面上项目(31370891)。
