摘要
以甜菊苷为原料,经水解、酯化、Fischer法合成了11个新型异斯特维醇吲哚衍生物3a^3k。探索出水解反应的中试条件,开发了石油醚/乙酸乙酯混合溶剂法重结晶精制化合物2,Fischer吲哚合成法合成的目标产物收率为64%~93%,结构经1H NMR、HR-MS和FT-IR表征。
Eleven novel isosteviol-indole derivatives 3a^3k were synthesized by acid hydrolysis,esterification and Fischer reactions from stevioside.The pilot-scale experimental conditions for the hydrolysis reaction was explored,and compound 2 was refined by the petroleum ether and ethyl acetate as mixed solvent.The yields of target products 3a^3k,synthesized by Fischer method,were 64%~93%.The structures were characterized by 1H NMR,HR-MS and FT-IR.
作者
刘从军
韦畅勇
赵国欣
王宇飞
陶京朝
LIU Cong-jun;WEI Chang-yong;ZHAO Guo-xin;WANG Yu-fei;TAO Jing-chao(Department of Chemical Engineering and Food Science,Zhengzhou Institute of Technology,Zhengzhou,450044,China;College of Chemistry and Molecular Engineering,Zhengzhou University,Zhengzhou,450001,China)
出处
《合成化学》
CAS
北大核心
2020年第11期971-976,共6页
Chinese Journal of Synthetic Chemistry
基金
河南省教育厅高等学校重点科研项目(20B350009)。
